ReviewCritical care (London, England)2023
The future of intensive care: the study of the microcirculation will help to guide our therapies.
Review in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 112 citations in OpenAlex.
- Anisodamine hydrobromide reduces 28-day mortality in septic shock: a randomized controlled.Frontiers in pharmacology · 2026Trial
- Iloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial.American journal of respiratory and critical care medicine · 2025Trial
- [Relationship between cardiac output, heart rate and microcirculation in patients with multiorgan dysfunction syndrome].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Trial
- Advancing Microcirculatory Therapies in Pediatric Sepsis: Current Opportunities and Future Directions.Journal of intensive care medicine · 2026Review
- The OxyCam: A novel hand-held vital microscope for quantitative measurement of microcirculatory perfusion and oxygenation.Journal of intensive medicine · 2026Article
- High vasopressor doses are associated with decreased tissue oxygenation in critically ill patients: a secondary analysis of a prospective cohort.Critical care (London, England) · 2026Article
- Assessment of the Microcirculation During Extracorporeal Blood Purification in Septic Patients: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices.Journal of stroke · 2026Review
- Beyond blood pressure: a comprehensive overview of clinical indices in shock and tissue hypoperfusion.Acute and critical care · 2026Article
- Comparison of norepinephrine with a combined non-catecholaminergic therapy in a porcine model of refractory cardiac arrest resuscitated with VA-ECMO.Intensive care medicine experimental · 2026Article
- Extending the frontier of tissue perfusion to monitoring the microcirculation.Intensive care medicine · 2026Article
- Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality.Critical care (London, England) · 2026Article
- Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review.Intensive care medicine · 2026Review
- Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitonin.Nature communications · 2026Article
- Ocular diseases and their association with mortality in intensive care unit patients: a retrospective cohort study from the MIMIC-IV database.BMJ open ophthalmology · 2026Article
- Dynamic microvascular monitoring with miniaturized omnidirectional broadband photoacoustic imaging system for living entities (MOBILE).Nature communications · 2026Article
- A two-phase core-plasma model for microvascular blood flow: Comparative analysis of hemodynamic models.PloS one · 2026Article
- Tissue Perfusion and Fluid Responsiveness Assessment in Critically Ill Patients. A Feasibility Pilot Study Using the Ikorus Urothelial Plethysmography Device (The Target-Up Study).Shock (Augusta, Ga.) · 2026Article
- Bedside measurement of microcirculation in critically ill patients: A scoping review protocol.PloS one · 2026Article
- Personalised fluid therapy in septic shock.Annals of intensive care · 2026Review
Corrections and comments
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Authors and funding
9 authors at 9 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the microcirculation of organs, which prevents them from achieving an additional degree of individualization of the hemodynamic resuscitation at tissue level. Indeed, clinicians never know whether optimization of the microcirculation and tissue oxygenation is actually achieved after macrovascular hemodynamic optimization. The challenge for the future is to have noninvasive, easy-to-use equipment that allows reliable assessment and immediate quantitative analysis of the microcirculation at the bedside. There are different methods for assessing the microcirculation at the bedside; all have strengths and challenges. The use of automated analysis and the future possibility of introducing artificial intelligence into analysis software could eliminate observer bias and provide guidance on microvascular-targeted treatment options. In addition, to gain caregiver confidence and support for the need to monitor the microcirculation, it is necessary to demonstrate that incorporating microcirculation analysis into the reasoning guiding hemodynamic resuscitation prevents organ dysfunction and improves the outcome of critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.