Evidence map›Paper›PMID 37193826›Full record

ArticleCommunications biology2023

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.

William Chour, Jongchan Choi, Jingyi Xie, Mary E Chaffee, Thomas M Schmitt, Kathryn Finton, Diana C DeLucia, Alexander M Xu, Yapeng Su, Daniel G Chen and 15 more

Abstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

William Chour *Institute for Systems Biology, Seattle, WA, 98109, USA.
Jongchan Choi *Institute for Systems Biology, Seattle, WA, 98109, USA.
Jingyi XieInstitute for Systems Biology, Seattle, WA, 98109, USA.ORCID 0000-0002-8959-4268
Mary E ChaffeeProgram in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Thomas M SchmittProgram in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Kathryn FintonProgram in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Diana C DeLuciaDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.ORCID 0000-0002-1165-6799
Alexander M XuInstitute for Systems Biology, Seattle, WA, 98109, USA.ORCID 0000-0003-4877-4358
Yapeng SuInstitute for Systems Biology, Seattle, WA, 98109, USA.
Daniel G ChenInstitute for Systems Biology, Seattle, WA, 98109, USA.ORCID 0000-0001-6660-6257
Rongyu ZhangInstitute for Systems Biology, Seattle, WA, 98109, USA.
Dan YuanInstitute for Systems Biology, Seattle, WA, 98109, USA.
Sunga HongInstitute for Systems Biology, Seattle, WA, 98109, USA.ORCID 0000-0003-4412-2811
Alphonsus H C NgInstitute for Systems Biology, Seattle, WA, 98109, USA.
Jonah Z ButlerProgram in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Rick A EdmarkInstitute for Systems Biology, Seattle, WA, 98109, USA.
Lesley C JonesInstitute for Systems Biology, Seattle, WA, 98109, USA.
Kim M MurrayInstitute for Systems Biology, Seattle, WA, 98109, USA.
Songming PengPACT Pharma, South San Francisco, CA, 94080, USA.
Guideng LiInstitute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Roland K StrongProgram in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
John K LeeDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.ORCID 0000-0002-6570-2180
Jason D GoldmanSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, 98104, USA.ORCID 0000-0002-3825-6832
Philip D GreenbergProgram in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.ORCID 0000-0003-3812-647X
James R HeathInstitute for Systems Biology, Seattle, WA, 98109, USA. Jheath@isbscience.org.ORCID 0000-0001-5356-4385

Funding

Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterizationR01CA264090 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI HEATH, JAMES R. · 2021 to 2025
$2.7M
TCR-like antibodies for HPV-induced cancer basic research and theranosticsR01AI121242 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STRONG, ROLAND K · 2016 to 2019
$1.7M
Identifying relevant HLA-F ligandsR21AI154874 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STRONG, ROLAND K · 2020 to 2021
$484k
NCI NIH HHS R01 CA264090NIAID NIH HHS R01 AI121242NIAID NIH HHS R21 AI154874
6 · The paper itself

Abstract

The discovery and characterization of antigen-specific CD8

Indexed as

CD8-Positive T-LymphocytesCOVID-19AntigensEpitopesHumansPeptidesSARS-CoV-2AntigensEpitopesPeptides

Identifiers

PMID37193826
PMCPMC10186326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.