ArticleNature communications2023
Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Ionic weaving network enables mechanically robust smart hydrogels with anti-swelling and anti-freezing capabilities.Nature communications · 2026Article
- Phase-separated hydrogels for advanced biomedical engineering: From material design to applications.Materials today. Bio · 2026Review
- Advances in Strategies for Colloidal Self-Assembly.Chemical reviews · 2026Review
- Article
- Arresting Microphase Separation Encodes Material Mechanics by Sculpting Microarchitectures and Local Polymer Enrichment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Harnessing Phase Separation for the Development of High-Performance Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Perovskite nanocrystals-in-glass hierarchical structures enable stable continuous-wave random lasers.Science advances · 2026Article
- Gel-Gel Interface Engineering for the Synthesis of Anisotropic Hydrogels with Designable Polymer Orientations.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- "Twin-Chain" Hydrogels with Tailored Porosity, Surface Roughness, and Cleaning Capabilities.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- A Universal Strategy to Mitigate Microphase Separation via Cellulose Nanocrystal Hydration in Fabricating Strong, Tough, and Fatigue-Resistant Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Multimaterial cryogenic printing of three-dimensional soft hydrogel machines.Nature communications · 2025Article
- Self-Organized Vascularized Hepatic Organoids in Microcapsules for Liver Regeneration.Research (Washington, D.C.) · 2025Article
- An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs.Bio-design and manufacturing · 2024Article
- Compliant Iontronic Triboelectric Gels with Phase-Locked Structure Enabled by Competitive Hydrogen Bonding.Nano-micro letters · 2024Article
- Highly Strong, Tough, and Cryogenically Adaptive Hydrogel Ionic Conductors via Coordination Interactions.Research (Washington, D.C.) · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Engineering heterogeneous hydrogels with distinct phases at various lengths, which resemble biological tissues with high complexity, remains challenging by existing fabricating techniques that require complicated procedures and are often only applicable at bulk scales. Here, inspired by ubiquitous phase separation phenomena in biology, we present a one-step fabrication method based on aqueous phase separation to construct two-aqueous-phase gels that comprise multiple phases with distinct physicochemical properties. The gels fabricated by this approach exhibit enhanced interfacial mechanics compared with their counterparts obtained from conventional layer-by-layer methods. Moreover, two-aqueous-phase gels with programmable structures and tunable physicochemical properties can be conveniently constructed by adjusting the polymer constituents, gelation conditions, and combining different fabrication techniques, such as 3D-printing. The versatility of our approach is demonstrated by mimicking the key features of several biological architectures at different lengths: macroscale muscle-tendon connections; mesoscale cell patterning; microscale molecular compartmentalization. The present work advances the fabrication approach for designing heterogeneous multifunctional materials for various technological and biomedical applications.
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Registered trials
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