ArticleNature communications2023
A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 94 citations in OpenAlex.
- The microbiota at the interface of environmental toxicants and the brain.Cell metabolism · 2026Review
- Cellular and systemic modifiers of alpha-synuclein proteostasis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Pre-Reduction-Activated Carbon-Based Zinc Vanadate Nanosheet Composite with Zn-O-V Performance Synergy for Machine Learning-Enabled Multiplex Pesticide Detection.Nanomaterials (Basel, Switzerland) · 2026Article
- Pesticide exposure and multidomain symptom burden in Parkinson's disease: a longitudinal triangulation study.NPJ Parkinson's disease · 2026Article
- Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation.FEBS open bio · 2026Article
- DYRK1A and Parkinson's disease, facts and hypotheses.Neurobiology of disease · 2026Review
- High-Throughput Suspect Screening Reveals Widespread Pesticide Exposure in Early Childhood.Environment & health (Washington, D.C.) · 2026Article
- Prime editing in neuropsychiatric disorders: From mutation-specific target selection to clinical translation.Neuroprotection (Chichester, England) · 2026Review
- Dual-Risk axis:Journal of Parkinson's disease · 2026Article
- Preventing Parkinson's disease in the context of movement disorders: a narrative review of current evidence and future directions.Neurological research and practice · 2026Review
- Parkinson's disease: pathogenesis and therapeutic strategies.Molecular biomedicine · 2026Review
- High pesticide exposure events and subjective cognitive complaints among US farmers.Environmental research · 2026Article
- Duration of agricultural pesticide exposure application and Parkinson's disease in California's central valley.Environmental research, health : ERH · 2026Article
- Cytoprotective Mechanism of Necrox-5 Against Toxicity Induced by Experimental Ferroptosis Instigators and the Pesticide Propargite.International journal of molecular sciences · 2026Article
- Pesticides and parkinson's disease: causal relationship at the population and individual level?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Identification of pesticides associated with an increased risk of Parkinson's disease using a multi-screen approach.Environment international · 2026Article
- Agricultural Copper Pesticide Exposure and Metabolic Profiles among Parkinson's Disease Cases and Community Controls in California.Chemical research in toxicology · 2026Article
- Marked Clinical Improvement in Parkinson's Disease Following Double-Filtration Apheresis: A Case Report.Degenerative neurological and neuromuscular disease · 2026Article
- Interface-Adaptive Dual-Color Hydrogel with Self-Repairing Function and High Adhesion as Flexible Wearable Sensor for Minimally-Invasive Monitoring Pesticide Residue in Living Crop.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pharmacological modulation of p75 neurotrophin receptor in microglial cells improves resilience to rotenone cytotoxicity.Frontiers in pharmacology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 8 institutions in 1 country.
Funding
Abstract
Parkinson's disease (PD) is a complex neurodegenerative disease with etiology rooted in genetic vulnerability and environmental factors. Here we combine quantitative epidemiologic study of pesticide exposures and PD with toxicity screening in dopaminergic neurons derived from PD patient induced pluripotent stem cells (iPSCs) to identify Parkinson's-relevant pesticides. Agricultural records enable investigation of 288 specific pesticides and PD risk in a comprehensive, pesticide-wide association study. We associate long-term exposure to 53 pesticides with PD and identify co-exposure profiles. We then employ a live-cell imaging screening paradigm exposing dopaminergic neurons to 39 PD-associated pesticides. We find that 10 pesticides are directly toxic to these neurons. Further, we analyze pesticides typically used in combinations in cotton farming, demonstrating that co-exposures result in greater toxicity than any single pesticide. We find trifluralin is a driver of toxicity to dopaminergic neurons and leads to mitochondrial dysfunction. Our paradigm may prove useful to mechanistically dissect pesticide exposures implicated in PD risk and guide agricultural policy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.