Evidence map›Paper›PMID 37193511›Full record

ArticleJournal of the American Statistical Association2023

Conditional Functional Graphical Models.

Kuang-Yao Lee, Dingjue Ji, Lexin Li, Todd Constable, Hongyu Zhao

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kuang-Yao LeeDepartment of Statistical Science, Temple University, Philadelphia, PA.
Dingjue JiDepartment of Biostatistics, Yale University, New Haven, CT.
Lexin LiDivision of Biostatistics, University of California, Berkeley, CA.
Todd ConstableDepartment of Biostatistics, Yale University, New Haven, CT.
Hongyu ZhaoDepartment of Biostatistics, Yale University, New Haven, CT.

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Novel statistical methods and tools to integrate multiple endophenotypes and functional annotation data to study the roles of rare variants in complex human diseases using sequencing dataR01GM134005 · NIGMS · YALE UNIVERSITY · PI WU, BAOLIN, ZHAO, HONGYU · 2020 to 2023
$1.6M
New Statistical Methods for Multicenter Multimodal Longitudinal Neuroimaging AnalysisR01AG061303 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LI, LEXIN · 2019 to 2022
$1.5M
NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG061303NIA NIH HHS R01 AG062542NIGMS NIH HHS R01 GM134005
6 · The paper itself

Abstract

Graphical modeling of multivariate functional data is becoming increasingly important in a wide variety of applications. The changes of graph structure can often be attributed to external variables, such as the diagnosis status or time, the latter of which gives rise to the problem of dynamic graphical modeling. Most existing methods focus on estimating the graph by aggregating samples, but largely ignore the subject-level heterogeneity due to the external variables. In this article, we introduce a conditional graphical model for multivariate random functions, where we treat the external variables as conditioning set, and allow the graph structure to vary with the external variables. Our method is built on two new linear operators, the conditional precision operator and the conditional partial correlation operator, which extend the precision matrix and the partial correlation matrix to both the conditional and functional settings. We show that their nonzero elements can be used to characterize the conditional graphs, and develop the corresponding estimators. We establish the uniform convergence of the proposed estimators and the consistency of the estimated graph, while allowing the graph size to grow with the sample size, and accommodating both completely and partially observed data. We demonstrate the efficacy of the method through both simulations and a study of brain functional connectivity network.

Indexed as

Brain connectivity analysisFunctional magnetic resonance imagingGraphical modelKarhunen–Loève expansionLinear operatorReproducing kernel Hilbert space

Identifiers

PMID37193511
PMCPMC10181795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.