Evidence map›Paper›PMID 37193301›Full record

ArticleInfection and drug resistance2023

Declined Humoral Immunity of Kidney Transplant Recipients to SARS-CoV-2 Vaccines.

Waleed H Mahallawi, Wael A Alharbi, Sultan A Aloufi, Nadir A Ibrahim, Muntasir M Abdelrahman, Bader A Alhomayeed, Moutasem S Aboonq, Saeed Awad M Alqahtani, Emad S Rajih, Abdulaziz M Bakhsh and 1 more

Open access · goldAbstract read
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In one paragraph

Article in Infection and drug resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Waleed H MahallawiMedical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.ORCID 0000-0001-6977-9006
Wael A AlharbiMedical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
Sultan A AloufiMedical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
Nadir A IbrahimMedical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.ORCID 0000-0001-9440-8805
Muntasir M AbdelrahmanKing Fahad Hospital, Ministry of Health, Madinah, Saudi Arabia.
Bader A AlhomayeedKing Fahad Hospital, Ministry of Health, Madinah, Saudi Arabia.
Moutasem S AboonqDepartment of Physiology, College of Medicine, Taibah University, Madinah, Saudi Arabia.ORCID 0000-0002-9137-941X
Saeed Awad M AlqahtaniDepartment of Physiology, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Emad S RajihUrology Department, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Abdulaziz M BakhshUrology Department, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Ibrahim SandokjiDepartment of Pediatrics, College of Medicine, Taibah University, Madinah, Saudi Arabia.ORCID 0000-0003-1395-9555
Taibah University · SAMinistry of Health · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Kidney transplant recipients (KTRs) commonly suffer from impaired immunity. KTRs' compromised immune response to COVID-19 vaccines indicates urgent revision of immunisation policies. Methods: A cross-sectional study was conducted in Madinah, Saudi Arabia of 84 KTRs who had received at least one dose of a COVID-19 vaccine. ELISA was used to evaluate anti-spike SARS-CoV-2 IgG and IgM antibody levels in blood samples obtained one month and seven months after vaccination. Univariate and multivariate analyses were performed to identify associations between seropositive status and factors such as the number of vaccine doses, transplant age, and immunosuppressive therapies. Results: The mean age of KTRs was 44.3 ± 14.7 years. The IgG antibody seropositivity rate (n=66, 78.5%) was significantly higher than the seronegativity rate (n=18, 21.4%) in the whole cohort (p<0.001). In KTRs seroconverting after one month (n=66), anti-SARS-CoV-2 IgG levels declined significantly between one month (median [IQR]:3 [3-3]) and seven months (2.4 [1.7-2.6]) after vaccination (p<0.01). In KTRs with hypertension, IgG levels significantly decreased between one and seven months after vaccination (p<0.01). IgG levels also decreased significantly in KTRs with a transplant of >10 years (p=0.02). Maintenance immunosuppressive regimens (triple immunosuppressive therapy and steroid-based and antimetabolite-based regimens) led to a significant decrease in IgG levels between the first and second sample (p<0.01). KTRs receiving three vaccine doses showed higher antibody levels than those receiving a single dose or two doses, but the levels decreased significantly between one (median [IQR]: 3 [3-3]) and seven months (2.4 [1.9-2.6]) after vaccination (p<0.01). Conclusion: KTRs' humoral response after SARS-CoV-2 vaccination is dramatically inhibited and wanes. Antibody levels show a significant decline over time in KTRs with hypertension; receiving triple immunosuppressive therapy or steroid-based or antimetabolite-based regimens; receiving mixed mRNA and viral vector vaccines; and with a transplant of >10 years.

Indexed as

boosterCOVID-19 vaccineshumoral immune responseimmunosuppressionkidney transplant recipientsSARS-CoV-2

Identifiers

PMID37193301
PMCPMC10182766
OpenAlexW4376871821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.