ArticleAmerican journal of translational research2023
Clinical effect of cold and heat ablation on patients with advanced lung cancer and its influence on immune function.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Survival after radiofrequency ablation and/or chemotherapy for lung cancer and pulmonary metastases: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Comparison of the efficacy and adverse events between argon-helium cryoablation and microwave ablation for non-small cell lung cancer: a propensity score matching study.Journal of thoracic disease · 2025Article
- Efficacy of argon-helium cryoablation combined with chemotherapy in the treatment of advanced NSCLC.Pakistan journal of medical sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to explore the clinical effect of cold and heat ablation on patients with advanced lung cancer (LC) and its influence on immune function.
methodsData of 104 cases of advanced LC treated between July 2015 and April 2017 in the First Affiliated Hospital of Hunan University of Chinese Medicine were retrospectively analyzed. Among them, 49 patients receiving argon helium cryoablation (AHC) were regarded as group A, and 55 patients receiving radiofrequency ablation (RFA) were regarded as group B. The short-term postoperative efficacy and local tumour control rate were compared between the two groups. The changes in immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) were compared between the two groups before and after treatment. After treatment, the changes in carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21-1) were compared between the two groups. During the treatment, the complications and incidence of adverse reactions were compared between the two groups. Cox regression analysis was applied to analyze the factors influencing the prognosis of patients.
resultsThere was no statistical difference in IgA, IgG and IgM between the two groups after treatment (P>0.05). There was no statistical difference in CEA and CYFRA21-1 between the two groups after treatment (P>0.05). There was no notable difference in disease control rate and response rate between the two groups at 3 and 6 months after operation (P>0.05). The incidence of pleural effusion in group A was obviously lower than that in group B (P<0.05). The incidence of intraoperative pain in group A was obviously higher than that in group B (P<0.05). Age, clinical stage, CEA and CYFRA21-1 were found to be independent prognostic factors impacting overall survival (P<0.05).
conclusionAHC and RFA are minimally invasive procedures that lead to few complications in the treatment of advanced LC. Cold and heat ablation is a relatively safe and effective minimally invasive technique for tumour treatment, which is worthy of application and promotion in the clinical treatment of LC.
Indexed as
Identifiers
37193184PMC10182500W4376871580What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.