ArticleAmerican journal of translational research2023
Effects of neoadjuvant chemotherapy combined with breast-conserving surgery on the breast cancer condition and immune and inflammatory indexes of patients with breast cancer.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 0 citations in OpenAlex.
- Prognostic value of CA15-3, CA125, CEA in breast cancer patients undergoing chemotherapy.Journal of medical biochemistry · 2025Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effects of neoadjuvant chemotherapy combined with breast-conserving surgery (BCS) on the breast cancer (BC) condition and immune and inflammatory indexes of patients with BC.
methodsA total of 114 patients with BC admitted to the First People's Hospital of Shangqiu from March 2018 to March 2020 were retrospectively enrolled in this study. Fifty-four patients who underwent radical mastectomy alone were enrolled into the control group (Con group), and the other 60 patients who received neoadjuvant chemotherapy combined with BCS were assigned to the observation group (Obs group). The two groups were compared in terms of surgical indexes, therapeutic effects, immune indexes including immunoglobulin IgG, IgA, IgM, and inflammatory indexes. Cox regression analysis was conducted to analyze the independent prognostic factors of overall survival (OS) and disease-free survival (DFS).
resultsAfter therapy, the Obs group yielded a significantly higher effective therapy rate than the Con group and experienced notably shorter hospital stay and operation time than the Con group. In addition, the Obs group showed significantly higher levels of IgG, IgA and IgM and significantly lower levels of TNF-α and IL-6 than the Con group after therapy. According to Cox regression analysis, clinical stage and HER2 were independent prognostic factors impacting patients' OS and DFS.
conclusionNeoadjuvant chemotherapy combined with BCS can substantially alleviate the disease condition, effectively improve the immune ability, and lower the inflammation level of BC patients, without impacting their 2-year OS and DFS.
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Identifiers
37193161PMC10182502W4376871350What OpenQuestion holds
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