Evidence map›Paper›PMID 37192725›Full record

ArticleVirus research2023

SARS-CoV-2 omicron sub-lineages differentially modulate interferon response in human lung epithelial cells.

Gianni Gori Savellini, Gabriele Anichini, Maria Grazia Cusi

Open access · goldAbstract read
In one paragraph

Article in Virus research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gianni Gori SavelliniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy. Policlinico Santa Maria delle Scotte, Viale Bracci, 1, Siena 53100, Italy. Electronic address: gianni.gori@unisi.it.
Gabriele AnichiniDepartment of Medical Biotechnologies, University of Siena, Siena, Italy. Policlinico Santa Maria delle Scotte, Viale Bracci, 1, Siena 53100, Italy.
Maria Grazia CusiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy. Policlinico Santa Maria delle Scotte, Viale Bracci, 1, Siena 53100, Italy; Microbiology and Virology Unit, Santa Maria delle Scotte Hospital, Viale Bracci, 1, Siena 53100, Italy.
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although most of the attention was focused on the characterization of changes in the Spike protein among variants of SARS-CoV-2 virus, mutations outside the Spike region are likely to contribute to virus pathogenesis, virus adaptation and escape to the immune system. Phylogenetic analysis of SARS-CoV-2 Omicron strains reveals that several virus sub-lineages could be distinguished, from BA.1 up to BA.5. Regarding BA.1, BA.2 and BA.5, several mutations concern viral proteins with antagonistic activity to the innate immune system, such as NSP1 (S

Indexed as

COVID-19InterferonsAtaxia Telangiectasia Mutated ProteinsEpithelial CellsHumansInterferon-betaPhylogenySARS-CoV-2Spike Glycoprotein, CoronavirusAtaxia Telangiectasia Mutated ProteinsInterferon-betaInterferonsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Innate immunityInterferon antagonismOmicronORF6SARS-CoV-2

Identifiers

PMID37192725
PMCPMC10191105
OpenAlexW4376871775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.