ArticleNeuron2023
Social odor discrimination and its enhancement by associative learning in the hippocampal CA2 region.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Oxytocin receptor signaling in the dorsal lateral septum is essential for social transmission of food preference in mice.PLoS biology · 2026Article
- Dysfunction of hippocampal cells and its role in cognitive impairment.Neural regeneration research · 2026Article
- Neuroligin1 in CCK-interneurons gates social memory formation via a disinhibitory microcircuit in the hippocampal CA2 in male mice.Nature communications · 2026Article
- Social valence dictates sex differences in identity recognition.Translational psychiatry · 2026Article
- Similar processing of novelty in rat dorsal and intermediate CA1 despite differences in spatial tuning.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal-cortical interactions in the consolidation of social memory.Nature communications · 2025Article
- A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.Current biology : CB · 2025Article
- Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region.Cell reports · 2025Article
- Article
- Intranasal Transplantation of Microbiota Derived from Parkinson's Disease Mice Induced Astrocyte Activation and Neurodegenerative Pathology from Nose to Brain.Brain sciences · 2025Article
- Social odors drive hippocampal CA2 place cell responses to social stimuli.Progress in neurobiology · 2025Article
- Striatal and hippocampal contributions to instrumental learning in the mouse using high-resolution behavioral monitoring and fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The hippocampal CA2 region discriminates social threat from social safety.Nature neuroscience · 2024Article
- Social odors drive hippocampal CA2 place cell responses to social stimuli.bioRxiv : the preprint server for biology · 2024Article
- Comparative analysis of gonadal hormone receptor expression in the postnatal house mouse, meadow vole, and prairie vole brain.Hormones and behavior · 2024Article
- Associative learning and recollection of olfactory memory during the respiratory cycle in mammals: how is the self cognized in consciousness?Frontiers in neuroscience · 2024Article
- An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.Neuron · 2023Article
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3 authors.
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Abstract
Although the hippocampus is crucial for social memory, how social sensory information is combined with contextual information to form episodic social memories remains unknown. Here, we investigated the mechanisms for social sensory information processing using two-photon calcium imaging from hippocampal CA2 pyramidal neurons (PNs)-which are crucial for social memory-in awake head-fixed mice exposed to social and non-social odors. We found that CA2 PNs represent social odors of individual conspecifics and that these representations are refined during associative social odor-reward learning to enhance the discrimination of rewarded compared with unrewarded odors. Moreover, the structure of the CA2 PN population activity enables CA2 to generalize along categories of rewarded versus unrewarded and social versus non-social odor stimuli. Finally, we found that CA2 is important for learning social but not non-social odor-reward associations. These properties of CA2 odor representations provide a likely substrate for the encoding of episodic social memory.
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