ArticleCell2023
Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale.
Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 68 citations in OpenAlex.
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- Synchronization properties in C. elegans: Relating behavioral circuits to structural and functional neuronal connectivity.PLoS computational biology · 2026Article
- Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state.eLife · 2026Article
- SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution.eLife · 2026Article
- Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state inbioRxiv : the preprint server for biology · 2026Article
- Neural sequences underlying directed turning in Caenorhabditis elegans.Nature neuroscience · 2026Article
- Simple input-output dependencies explain neuronal activity.Nature physics · 2026Article
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans.Current biology : CB · 2026Article
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- Eyeless light sensing promotes thermotolerance.Cell research · 2026Article
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- Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans.Nature communications · 2026Article
- Neuromodulation of swarming behavior inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Deep neural networks to register and annotate cells in moving and deforming nervous systems.eLife · 2026Article
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits inFrontiers in systems neuroscience · 2026Review
- Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
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Abstract
Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse receptors across the brain to modulate global activity and behavior is unknown. Here, we examine how serotonin release in C. elegans alters brain-wide activity to induce foraging behaviors, like slow locomotion and increased feeding. Comprehensive genetic analyses identify three core serotonin receptors (MOD-1, SER-4, and LGC-50) that induce slow locomotion upon serotonin release and others (SER-1, SER-5, and SER-7) that interact with them to modulate this behavior. SER-4 induces behavioral responses to sudden increases in serotonin release, whereas MOD-1 induces responses to persistent release. Whole-brain imaging reveals widespread serotonin-associated brain dynamics, spanning many behavioral networks. We map all sites of serotonin receptor expression in the connectome, which, together with synaptic connectivity, helps predict which neurons show serotonin-associated activity. These results reveal how serotonin acts at defined sites across a connectome to modulate brain-wide activity and behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.