Evidence map›Paper›PMID 37192618›Full record

ArticleCell2023

A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity.

Xiao Yu, Yingpeng Xie, Dexian Luo, Hai Liu, Marcos V V de Oliveira, Peipei Qi, Sung-Il Kim, Fausto Andres Ortiz-Morea, Jun Liu, Yafei Chen and 6 more

Open access · greenAbstract read
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 68 citations in OpenAlex.

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  14. SERK5 genetically compensates for the loss of BAK1 and BKK1 in regulating elf18-triggered immune signaling inProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Xiao YuDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA; National Key Laboratory of Agricultural Microbiology, Hubei Key Laboratory of Plant Pathology, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Yingpeng XieDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Dexian LuoDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA; State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong 271018, China.
Hai LiuCollege of Life Science and Technology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Marcos V V de OliveiraDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Peipei QiNational Key Laboratory of Agricultural Microbiology, Hubei Key Laboratory of Plant Pathology, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Sung-Il KimDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Fausto Andres Ortiz-MoreaDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Jun LiuDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Yafei ChenNational Key Laboratory of Agricultural Microbiology, Hubei Key Laboratory of Plant Pathology, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Sixue ChenDepartment of Biology, University of Mississippi, Oxford, MS 38677, USA.
Bárbara RodriguesDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA.
Bo LiDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA; National Key Laboratory of Agricultural Microbiology, Hubei Key Laboratory of Plant Pathology, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Shaowu XueCollege of Life Science and Technology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Ping HeDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA. Electronic address: pinghe@tamu.edu.
Libo ShanDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA. Electronic address: lshan@tamu.edu.
Texas A&M University · USHuazhong Agricultural University · CNShandong Agricultural University · CNUniversity of Mississippi · US

Funding

Differential regulation of plant innate immunityR01GM092893 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HE, PING · 2010 to 2022
$2.7M
Immune signal perception and integration by cell surface receptors and peptide ligandsR35GM144275 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Libo Shan · 2022 to 2026
$2.2M
Signaling activation and constraints in maintaining immune homeostasisR35GM149197 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ping He · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM092893NIGMS NIH HHS R35 GM144275NIGMS NIH HHS R35 GM149197
6 · The paper itself

Abstract

Enabling and constraining immune activation is of fundamental importance in maintaining cellular homeostasis. Depleting BAK1 and SERK4, the co-receptors of multiple pattern recognition receptors (PRRs), abolishes pattern-triggered immunity but triggers intracellular NOD-like receptor (NLR)-mediated autoimmunity with an elusive mechanism. By deploying RNAi-based genetic screens in Arabidopsis, we identified BAK-TO-LIFE 2 (BTL2), an uncharacterized receptor kinase, sensing BAK1/SERK4 integrity. BTL2 induces autoimmunity through activating Ca

Indexed as

ArabidopsisPlant ImmunityArabidopsis ProteinsProtein KinasesProtein Serine-Threonine KinasesReceptors, Pattern RecognitionSignal TransductionArabidopsis ProteinsProtein KinasesProtein Serine-Threonine KinasesReceptors, Pattern Recognitionco-receptorimmune homeostasisleucine-rich repeat receptor kinaseNLRNOD-like receptorpattern recognition receptorphosphorylationphytocytokinePRR

Identifiers

PMID37192618
PMCPMC10281528
OpenAlexW4376620124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.