Evidence map›Paper›PMID 37192614›Full record

ArticleStructure (London, England : 1993)2023

Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.

Spencer Cholak, James W Saville, Xing Zhu, Alison M Berezuk, Katharine S Tuttle, Omid Haji-Ghassemi, Francisco J Alvarado, Filip Van Petegem, Sriram Subramaniam

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Cylindrical Crystallization of CaInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Phosphorylation of RYR1 at SerScience signaling · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Significance of ZnThe journal of physical chemistry. B · 2024
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Spencer CholakDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
James W SavilleDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Xing ZhuDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Alison M BerezukDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Katharine S TuttleDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Omid Haji-GhassemiDepartment of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada.
Francisco J AlvaradoDepartment of Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Filip Van PetegemDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: petegem@mail.ubc.ca.
Sriram SubramaniamDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: sriram.subramaniam@ubc.ca.
University of British Columbia · CAUniversity of Calgary · CAUniversity of Wisconsin–Madison · US

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasR01HL167195 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado, Hector H Valdivia · 2023 to 2026
$2.4M
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathyR01HL161070 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL161070NHLBI NIH HHS R01 HL167195NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

The coordinated release of Ca

Indexed as

NucleotidesRyanodine Receptor Calcium Release ChannelAdenineAdenosineAdenosine MonophosphateAdenosine TriphosphateAnimalsCalciumHumansMuscle, SkeletalRabbitsAdenineAdenosineAdenosine MonophosphateAdenosine TriphosphateCalciumNucleotidesRyanodine Receptor Calcium Release Channelcryo-EMnucleotide bindingRyanodine ReceptorRyR1

Identifiers

PMID37192614
PMCPMC10569317
OpenAlexW4376605182

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.