Evidence map›Paper›PMID 37192420›Full record

ArticleOrganic letters2023

α-Vinylation of Ester Equivalents via Main Group Catalysis for the Construction of Quaternary Centers.

Chloe G Williams, Sepand K Nistanaki, Conner W Wells, Hosea M Nelson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chloe G WilliamsDepartment of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0001-5090-8146
Sepand K NistanakiDepartment of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Conner W WellsDepartment of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Hosea M NelsonDepartment of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4666-2793
California Institute of Technology · US

Funding

Kinetically-Persistent Carbocationsin C-H Insertion Reactions and Biomimetic Cyclization CascadesR35GM128936 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NELSON, HOSEA MARTIN · 2018 to 2022
$1.9M
NIGMS NIH HHS R35 GM128936
6 · The paper itself

Abstract

A methodology for the construction of sterically congested quaternary centers via the trapping of vinyl carbocations with silyl ketene acetals is disclosed. This main group-catalyzed α-vinylation reaction is advantageous as methods to access these congested motifs are limited. Moreover, β,γ-unsaturated carbonyl moieties and tetrasubstituted alkenes are present in various bioactive natural products and pharmaceuticals, and this catalytic platform offers a means of accessing them using simple and inexpensive materials.

Identifiers

PMID37192420
PMCPMC10226172
OpenAlexW4376871103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.