ArticleJournal of the American Chemical Society2023
Ni-Electrocatalytic Enantioselective Doubly Decarboxylative C(sp
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Stereoretentive decarbonylative C(spNature · 2026Article
- Nickel-catalyzed hydroxymethylation with α-siliconChemical science · 2026Article
- Nickel-Catalyzed α‑Arylation and Alkenylation of α‑Trifluoromethyl Amines via 1,2-HAT Assisted by DMSO.JACS Au · 2026Article
- Cross-ketone deacylative coupling via oxidative SNature communications · 2026Article
- Use of Electron-Transfer Mediators to Access Higher Electrochemical Current Densities in Ni-Catalyzed Cross-Electrophile Coupling.Journal of the American Chemical Society · 2025Article
- β-Quaternary α-Amino Acids via Iridium-Catalyzed Branched and Enantioselective Hydroalkylation of 1,1-Disubstituted Styrenes.Angewandte Chemie (International ed. in English) · 2025Article
- Palladium-Catalyzed Oxidative Allene-Allene Cross-Coupling.Journal of the American Chemical Society · 2025Article
- Stereoselective amino alcohol synthesis via chemoselective electrocatalytic radical cross-couplings.Nature chemistry · 2025Article
- Reductive deaminative cross-coupling of alkyl bistriflimides enabled by electrocatalysis.Science advances · 2024Article
- Highly Enantioselective Decarboxylative Difluoromethylation.Journal of the American Chemical Society · 2024Article
- A decarbonylative approach to alkylnickel intermediates and C(spScience (New York, N.Y.) · 2024Article
- Photoelectrochemical Ni-catalyzed cross-coupling of aryl bromides with amine at ultra-low potential.Nature communications · 2024Article
- Deoxygenative radical cross-coupling of C(spNature communications · 2024Article
- Electroreductive deuteroarylation of alkenes enabled by an organo-mediator.Chemical science · 2024Article
- Electrochemical stereoselective synthesis of polysubstituted 1,4-dicarbonylChemical science · 2024Article
- Enantioselective nickel-catalyzed anodic oxidative dienylation and allylation reactions.Nature communications · 2024Article
- Alcohol-alcohol cross-coupling enabled by SScience (New York, N.Y.) · 2024Article
- Recent advances in catalytic asymmetric synthesis.Frontiers in chemistry · 2024Review
- A review of recent advances in electrochemical and photoelectrochemical late-stage functionalization classified by anodic oxidation, cathodic reduction, and paired electrolysis.Beilstein journal of organic chemistry · 2024Review
- Temperature-Dependent Spontaneous Resolution of a Tetrahedral Chiral-at-Nickel(II) Complex under Supramolecular Control.ACS organic & inorganic Au · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The first examples of enantioselective doubly decarboxylative cross coupling are disclosed. Malonate half amides are smoothly coupled to a variety of primary carboxylic acids after formation of the corresponding redox-active esters under Ni-electrocatalytic conditions using a new chiral ligand based on PyBox, resulting in amides with α-alkylated stereocenters. The scope of the reaction is broad, tolerating numerous functional groups, and uniformly proceeds with high ee. Finally, the potential utility of this enantioselective radical-radical reductive cross coupling to simplify synthesis is demonstrated with numerous case studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.