Evidence map›Paper›PMID 37192289›Full record

ArticleCirculation. Heart failure2023

Rethinking Donor and Recipient Risk Matching in Europe and North America: Using Heart Transplant Predictors of Donor and Recipient Risk.

Yasbanoo Moayedi, Eduard Rodenas-Alesina, Brigitte Mueller, Chun-Po S Fan, Wida S Cherikh, Josef Stehlik, Jeffrey J Teuteberg, Heather J Ross, Kiran K Khush

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. European Society of Organ Transplantation (ESOT) Consensus Statement on Machine Perfusion in Cardiothoracic Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Yasbanoo MoayediTed Rogers Centre for Heart Research (Y.M., E.R.-A., H.J.R.).ORCID 0000-0002-3288-7393
Eduard Rodenas-AlesinaTed Rogers Centre for Heart Research (Y.M., E.R.-A., H.J.R.).ORCID 0000-0003-1638-7820
Brigitte MuellerTed Rogers Computational Program (B.M., C.-P.S.F.), Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-1876-4722
Chun-Po S FanTed Rogers Computational Program (B.M., C.-P.S.F.), Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.
Wida S CherikhUnited Network for Organ Sharing, Richmond, VA (W.S.C.).ORCID 0000-0001-8156-6695
Josef StehlikDepartment of Medicine, Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City (J.S.).ORCID 0000-0002-7362-0513
Jeffrey J TeutebergSection of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, and Department of Medicine, Stanford University, CA (Y.M., J.J.T., K.K.K.).ORCID 0000-0002-8342-3222
Heather J RossTed Rogers Centre for Heart Research (Y.M., E.R.-A., H.J.R.).ORCID 0000-0003-4384-3027
Kiran K KhushSection of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, and Department of Medicine, Stanford University, CA (Y.M., J.J.T., K.K.K.).ORCID 0000-0001-9697-5926
Ted Rogers Centre for Heart Research · CAAssociation of Organ Procurement Organizations · USCardiovascular Institute of the South · USStanford Medicine · USUniversity of Utah · US

Funding

Evidence Based Evaluation and Acceptance of Donor Hearts for TransplantationR01HL125303 · NHLBI · STANFORD UNIVERSITY · PI KHUSH, KIRAN KAUR · 2015 to 2019
$3.0M
NHLBI NIH HHS R01 HL125303
6 · The paper itself

Abstract

backgroundIn Europe, there is greater acceptance of hearts from higher-risk donors for transplantation, whereas in North America, the donor heart discard rate is significantly higher. A Donor Utilization Score (DUS) was used to compare European and North American donor characteristics for recipients included in the International Society for Heart and Lung Transplantation registry from 2000 to 2018. DUS was further evaluated as an independent predictor for 1-year freedom from graft failure, after adjusting for recipient risk. Lastly, we assessed donor-recipient risk matching with the outcome of 1-year graft failure.

methodsDUS was applied to the International Society for Heart and Lung Transplantation cohort using meta-modeling. Posttransplant freedom from graft failure was summarized by Kaplan-Meier survival. Multivariable Cox proportional hazard regression was applied to quantify the effects of DUS and Index for Mortality Prediction After Cardiac Transplantation score on the 1-year risk of graft failure. We present 4 donor/recipient risk groups using the Kaplan-Meier method.

resultsEuropean centers accept significantly higher-risk donor hearts compared to North America. DUS 0.45 versus 0.54,

Indexed as

Heart FailureHeart TransplantationEuropeGraft SurvivalHumansNorth AmericaRetrospective StudiesTissue Donorsheart transplantationmachine learningrisktissue donorUnited States

Identifiers

PMID37192289
PMCPMC10195023
OpenAlexW4376638096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.