ArticleMicrobiology spectrum2023
Characteristics of the Salivary Microbiota in Periodontal Diseases and Potential Roles of Individual Bacterial Species To Predict the Severity of Periodontal Disease.
Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The Role of the Oral Microbiome in Periodontal Disease: A Systematic Review of Microbial Associations and Therapeutic Implications.Current microbiology · 2025Pooled it
- Evaluation of Therapeutic and Biopharmaceutical Properties of a Biadhesive Dental Paste Based on a Complex Immunoglobulin Preparation.Bulletin of experimental biology and medicine · 2026Article
- Correlating bacterial load and periodontal disease severity: A large-scale study of the microbial landscape.Journal of periodontology · 2026Article
- Microbial crosstalk along the oral-gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum.Neoplasia (New York, N.Y.) · 2026Review
- Tryptophan-Derived Microbial Metabolite Indole-3-Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1-Mediated Macrophage Polarisation.Journal of clinical periodontology · 2026Article
- Salivary microbial profiles across periodontal severity stage according to the 2018 AAP/EFP classifications: a cross-sectional study.Frontiers in oral health · 2026Article
- Compound Chamomile and Lidocaine Hydrochloride Gel in Oral Diseases: A Review of Current Evidence and Potential Applications.Drug design, development and therapy · 2026Review
- Identification of Bacterial Networks and Relationship to Host Responses in Early Periodontitis Population over 24 Months.International journal of molecular sciences · 2025Article
- Oral Microbiome Signatures in Periodontitis and Edentulism-A Population-Based Study.Journal of periodontal research · 2025Article
- SANA-Biome: A Protocol for a Cross-Sectional Study on Oral Health, Diet, and the Oral Microbiome in Romania.Healthcare (Basel, Switzerland) · 2025Article
- Reliability of partial-mouth periodontal examinations for diagnosing periodontal disease.Journal of periodontal & implant science · 2025Article
- Advanced biomaterials for targeting mature biofilms in periodontitis therapy.Bioactive materials · 2025Review
- Biosensors based on organic transistors for intraoral biomarker detection.Mikrochimica acta · 2025Review
- An Update of Salivary Biomarkers for the Diagnosis of Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Unraveling salivary microbiota diversity following kidney transplantation: insights from baseline peripheral blood lymphocyte subsets.Journal of oral microbiology · 2025Article
- Article
- Quantifying periodontitis-associated oral dysbiosis in tongue and saliva microbiomes-An integrated data analysis.Journal of periodontology · 2025Article
- Patients with periodontitis exhibit persistent dysbiosis of the gut microbiota and distinct serum metabolome.Journal of oral microbiology · 2025Article
- Comparative evaluation of antimicrobial toothpastes on periodontal bacteria in orthodontic patients: A randomized controlled study.Journal of orthodontic science · 2025Article
- Oral Pathogens' Substantial Burden on Cancer, Cardiovascular Diseases, Alzheimer's, Diabetes, and Other Systemic Diseases: A Public Health Crisis-A Comprehensive Review.Pathogens (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purposes of this study were to examine the compositional changes in the salivary microbiota according to the severity of periodontal disease and to verify whether the distribution of specific bacterial species in saliva can distinguish the severity of disease. Saliva samples were collected from 8 periodontally healthy controls, 16 patients with gingivitis, 19 patients with moderate periodontitis, and 29 patients with severe periodontitis. The V3 and V4 regions of the 16S rRNA gene in the samples were sequenced, and the levels of 9 bacterial species showing significant differences among the groups by sequencing analysis were identified using quantitative real-time PCR (qPCR). The predictive performance of each bacterial species in distinguishing the severity of disease was evaluated using a receiver operating characteristic curve. Twenty-nine species, including Porphyromonas gingivalis, increased as the severity of disease increased, whereas 6 species, including Rothia denticola, decreased. The relative abundances of P. gingivalis, Tannerella forsythia, Filifactor alocis, and Prevotella intermedia determined by qPCR were significantly different among the groups. The three bacterial species P. gingivalis, T. forsythia, and F. alocis were positively correlated with the sum of the full-mouth probing depth and were moderately accurate at distinguishing the severity of periodontal disease. In conclusion, the salivary microbiota showed gradual compositional changes according to the severity of periodontitis, and the levels of P. gingivalis,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.