Evidence map›Paper›PMID 37191509›Full record

ArticleInfection and immunity2023

Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress.

Alyssa Margolis, Lin Liu, Steffen Porwollik, James Karl A Till, Weiping Chu, Michael McClelland, Andrés Vázquez-Torres

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Microorganisms · 2026
    Review
  4. Inhibition of ascorbic acid on Pseudomonas bubulae under super-chilled storage.World journal of microbiology & biotechnology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Arginine at the host-pathogen interface.Infection and immunity · 2025
    Review
  15. Review
  16. Arginine utilization inInfection and immunity · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alyssa MargolisDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Lin LiuDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Steffen PorwollikDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, California, USA.
James Karl A TillDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Weiping ChuDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, California, USA.
Michael McClellandDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, California, USA.
Andrés Vázquez-TorresDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-6181-4185
University of Colorado Anschutz Medical Campus · USUniversity of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Salmonella evasion of NADPH oxidase-dependent killingR01AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2003 to 2018
$5.2M
Predoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7M
Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Barcoding a Salmonella gene knockout libraryR03AI139557 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MCCLELLAND, MICHAEL · 2019 to 2020
$157k
BLRD Research Career Scientist Award ApplicationIK6BX005384 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI VAZQUEZ-TORRES, ANDRES · 2021 to 2025
–
Development of DksA-targeted Antibiotics for Treatment of Gram-negative InfectionsI01BX005733 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Andres Vazquez-Torres · 2023 to 2026
–
Molecular Analysis of Bacterial Adaptive Response to Host Reactive SpeciesI01BX002073 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Andres Vazquez-Torres · 2013 to 2026
–
BLRD VA I01 BX002073BLRD VA I01 BX005733BLRD VA IK6 BX005384NCI NIH HHS P30 CA062203NIAID NIH HHS R01 AI054959NIAID NIH HHS R01 AI136520NIAID NIH HHS R03 AI139557NIAID NIH HHS T32 AI052066NIGMS NIH HHS T32 GM136444
6 · The paper itself

Abstract

Salmonella invades host cells and replicates inside acidified, remodeled vacuoles that are exposed to reactive oxygen species (ROS) generated by the innate immune response. Oxidative products of the phagocyte NADPH oxidase mediate antimicrobial activity, in part, by collapsing the ΔpH of intracellular Salmonella. Given the role of arginine in bacterial resistance to acidic pH, we screened a library of 54 single-gene mutants in Salmonella that are each involved in, but do not entirely block, arginine metabolism. We identified several mutants that affected Salmonella virulence in mice. The triple mutant Δ

Indexed as

MacrophagesOxidative StressAnimalsHydrogen PeroxideMiceNADPH OxidasesReactive Oxygen SpeciesSalmonellaHydrogen PeroxideNADPH OxidasesReactive Oxygen Speciesarginineinnate immunitymetabolismnox2oxidative stresspHphagocyte NADPH oxidaseSalmonella

Identifiers

PMID37191509
PMCPMC10269097
OpenAlexW4376640478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.