Evidence map›Paper›PMID 37191503›Full record

ArticleJournal of bacteriology2023

An Amino Acid Substitution in Elongation Factor EF-G1A Alters the Antibiotic Susceptibility of Pseudomonas aeruginosa LasR-Null Mutants.

Rhea G Abisado-Duque, Kade A Townsend, Brielle M Mckee, Kathryn Woods, Pratik Koirala, Alexandra J Holder, Vaughn D Craddock, Matthew Cabeen, Josephine R Chandler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Evolution of Resistant Mutants inMicroorganisms · 2025
    Article
  2. Regulation, structure, and activity of theAntimicrobial agents and chemotherapy · 2025
    Review
  3. Quorum-sensing regulation of phenazine production heightensAntimicrobial agents and chemotherapy · 2024
    Article
  4. A rise in the frequency ofFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rhea G Abisado-Duque *Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Kade A Townsend *Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Brielle M Mckee *Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Kathryn WoodsDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Pratik KoiralaDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Alexandra J HolderDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Vaughn D CraddockDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Matthew CabeenDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0001-8252-1050
Josephine R ChandlerDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0001-8944-9813
University of Kansas · USOklahoma State University · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
TRAINING GRANT IN DYNAMIC ASPECTS OF CHEMICAL BIOLOGYT32GM008545 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LAMB, AUDREY L · 1994 to 2019
$4.9M
500 NATIONS BRIDGE PROPOSAL--HASKELL/KANSAS UNIVERSITYR25GM060182 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI BURGIN, AMY, HOLDER, MELISSA · 1999 to 2019
$3.6M
Graduate Training at the Biology-Chemistry InterfaceT32GM132061 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Brian Douglas Ackley · 2020 to 2026
$2.9M
Quorum sensing evolution and function in mixed bacterial communitiesR35GM133572 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI CHANDLER, JOSEPHINE R · 2019 to 2024
$2.1M
MARC at The University of KansasT34GM136453 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Paulyn Cartwright, Stuart John Macdonald · 2020 to 2026
$1.9M
NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM103638NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R25 GM060182NIGMS NIH HHS R35 GM133572NIGMS NIH HHS T32 GM008545NIGMS NIH HHS T32 GM132061NIGMS NIH HHS T34 GM136453
6 · The paper itself

Abstract

The opportunistic bacterium Pseudomonas aeruginosa uses the LasR-I quorum-sensing system to increase resistance to the aminoglycoside antibiotic tobramycin. Paradoxically,

Indexed as

Pseudomonas aeruginosaPseudomonas InfectionsAmino Acid SubstitutionAnti-Bacterial AgentsBacterial ProteinsHumansMutationQuorum SensingTobramycinTrans-ActivatorsAnti-Bacterial AgentsBacterial ProteinsTobramycinTrans-Activatorsantibiotic resistanceevolutionLasRPseudomonas aeruginosaquorum sensingtobramycin

Identifiers

PMID37191503
PMCPMC10294626
OpenAlexW4376640603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.