Evidence map›Paper›PMID 37191427›Full record

ReviewAging and disease2023

Tryptophan Metabolism in Central Nervous System Diseases: Pathophysiology and Potential Therapeutic Strategies.

Yinrou Huang, Mengke Zhao, Xuemei Chen, Ruoyu Zhang, Anh Le, Michael Hong, Yufei Zhang, Lin Jia, Weidong Zang, Chao Jiang and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Yinrou HuangDepartment of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mengke ZhaoDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Xuemei ChenDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Ruoyu ZhangDepartment of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Anh LeProgram in the McKelvey School of Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Michael HongDepartment of Internal Medicine, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.
Yufei ZhangDepartment of Economics, University of Washington, WA 98125, USA.
Lin JiaDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Weidong ZangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Chao JiangDepartment of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Junmin WangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Xiaochong FanDepartment of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jian WangDepartment of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CNFifth Affiliated Hospital of Zhengzhou University · CNSinai Hospital · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal function. Altered TRP metabolism has been implicated in the pathophysiology of various diseases of the central nervous system. TRP is metabolized through two main pathways, the kynurenine pathway and the methoxyindole pathway. First, TRP is metabolized to kynurenine, then kynurenic acid, quinolinic acid, anthranilic acid, 3-hydroxykynurenine, and finally 3-hydroxyanthranilic acid along the kynurenine pathway. Second, TRP is metabolized to serotonin and melatonin along the methoxyindole pathway. In this review, we summarize the biological properties of key metabolites and their pathogenic functions in 12 disorders of the central nervous system: schizophrenia, bipolar disorder, major depressive disorder, spinal cord injury, traumatic brain injury, ischemic stroke, intracerebral hemorrhage, multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. Furthermore, we summarize preclinical and clinical studies, mainly since 2015, that investigated the metabolic pathway of TRP, focusing on changes in biomarkers of these neurologic disorders, their pathogenic implications, and potential therapeutic strategies targeting this metabolic pathway. This critical, comprehensive, and up-to-date review helps identify promising directions for future preclinical, clinical, and translational research on neuropsychiatric disorders.

Identifiers

PMID37191427
PMCPMC10187711
OpenAlexW4312580438

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.