Evidence map›Paper›PMID 37190888›Full record

ArticleJournal of Zhejiang University. Science. B2023

Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology.

Zhihang Hu, Modan Yang, Hao Chen, Chiyu He, Zuyuan Lin, Xinyu Yang, Huigang Li, Wei Shen, Di Lu, Xiao Xu

Open access · greenAbstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Functional characterization of double-negative T cells isolated from leukoreduction filter residues].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  2. SLAMF7 promotes TCRαβJournal of experimental & clinical cancer research : CR · 2025
    Article
  3. Lymphotoxin beta receptorInfection and immunity · 2025
    Article
  4. Article
  5. Strategies for Altering Delivery Technologies to Optimize CAR Therapy.International journal of molecular sciences · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zhihang HuZhejiang University School of Medicine, Hangzhou 310058, China.
Modan YangZhejiang University School of Medicine, Hangzhou 310058, China.
Hao ChenZhejiang University School of Medicine, Hangzhou 310058, China.
Chiyu HeZhejiang University School of Medicine, Hangzhou 310058, China.
Zuyuan LinZhejiang University School of Medicine, Hangzhou 310058, China.
Xinyu YangZhejiang University School of Medicine, Hangzhou 310058, China.
Huigang LiZhejiang University School of Medicine, Hangzhou 310058, China.
Wei ShenZhejiang University School of Medicine, Hangzhou 310058, China.
Di LuZhejiang University School of Medicine, Hangzhou 310058, China. zjuludi@zju.edu.cn.
Xiao XuZhejiang University School of Medicine, Hangzhou 310058, China. zjxu@zju.edu.cn.
Blood Center of Zhejiang Province · CNZhejiang Lab · CN

Funding

the Key Research & Development Plan of Zhejiang Province 2019C03050 and 2021C03118the National Key Research and Development Program of China 2021YFA1100500the National Natural Science Foundation of China 92159202
6 · The paper itself

Abstract

Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer. In addition to the common mechanisms underlying tumor recurrence, another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and metastasis. Transplant oncology is an emerging field that addresses oncological challenges in transplantation. In this context, a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of recipients. Double-negative T cells (DNTs) are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor (TCR) type. Among them, TCRαβ

Indexed as

Immunotherapy, AdoptiveT-LymphocytesCell- and Tissue-Based TherapyHumansNeoplasm Recurrence, LocalTransplantation, HomologousAdoptive cell therapy (ACT)Double-negative T cell (DNT)Liver cancerLiver transplantationOncology

Identifiers

PMID37190888
PMCPMC10186140
OpenAlexW4376642805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.