Evidence map›Paper›PMID 37190814›Full record

ReviewCurrent medicinal chemistry2024

Radiotherapy-associated Sensorineural Hearing Loss in Pediatric Oncology Patients.

Muhammad Ammar Aslam, Hassaan Ahmad, Hamza Sultan Malik, Herlina Uinarni, Yasir Salam Karim, Yusuf Makhmudovich Akhmedov, Walid Kamal Abdelbasset, Sura A Awadh, Mohammed Kadhem Abid, Yasser Fakri Mustafa and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Muhammad Ammar AslamDepartment of Emergency Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Hassaan AhmadDepartment of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Hamza Sultan MalikDepartment of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Herlina UinarniDepartment of Anatomy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Yasir Salam KarimAl-Manara College for Medical Sciences, Maysan, Iraq.
Yusuf Makhmudovich AkhmedovDepartment of Pediatric Surgery, Samarkand State Medical Institute, Samarkand, Uzbekistan.
Walid Kamal AbdelbassetDepartment of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.
Sura A AwadhDepartment of Anesthesia, Al-Mustaqbal University, Babylon, Iraq.
Mohammed Kadhem AbidDepartment of Anesthesia, College of Health & medical Technology, Al-Ayen University, Thi-Qar, Iraq.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.
Bagher FarhoodDepartment of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Amirhosein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Rawalpindi Medical University · PKAl-Nisour University College · IQAtma Jaya Catholic University of Indonesia · IDCairo University · EGKashan University of Medical Sciences · IRMashhad University of Medical Sciences · IRSamarkand State Medical Institute · UZThi Qar University · IQUniversity of Mosul · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the radiotherapeutic treatment of pediatric oncology patients, they would be at a latent risk of developing ionizing radiation-induced ototoxicity when the cochlea or auditory nerve is located within the radiation field. Sensorineural hearing loss (SNHL) is an irreversible late complication of radiotherapy, and its incidence depends on various factors such as the patient's hearing sensitivity, total radiation dose to the cochlea, radiotherapy fractionation regimen, age and chemoradiation. Importantly, this complication exhibits serious challenges to adult survivors of childhood cancer, as it has been linked to impairments in academic achievement, psychosocial development, independent living skills, and employment in the survivor population. Therefore, early detection and proper management can alleviate academic, speech, language, social, and psychological morbidity arising from hearing deficits. In the present review, we have addressed issues such as underlying mechanisms of radiation-induced SNHL, audiometric findings of pediatric cancer patients treated with radiotherapy, and management and protection measures against radiation-induced ototoxicity.

Indexed as

Hearing Loss, SensorineuralNeoplasmsChildHumansRadiation InjuriesRadiotherapychemoradiationchildhood cancer.ototoxicityPediatric cancerradiotherapysensorineural hearing loss

Identifiers

PMID37190814
OpenAlexW4376643023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.