Evidence map›Paper›PMID 37190776›Full record

SynthesisAnnals of medicine2023

Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review.

Mindan Wu, Zhixuan Li, Wenchuan Zheng, Jia Zhuang, Shuhan Wu, Qipeng Zhou, Junfu Cai, Houzhen Zheng, Guixing Zeng, Weilin Zhang and 4 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mindan WuDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Zhixuan LiDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Wenchuan ZhengDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Jia ZhuangDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Shuhan WuDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Qipeng ZhouDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Junfu CaiDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Houzhen ZhengDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Guixing ZengDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Weilin ZhangDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Shengbin ZhangDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Maohuang LinDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Xianyang ZhongDepartment of Gastroenterology, Shantou Central Hospital, Shantou, China.
Qichuan ZhangDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Shantou Central Hospital · CNShantou University Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo conduct a meta-analysis and systematic review on the association between anticholinergic medication uses and the risk of pneumonia in elderly adults. MATERIALS AND

methodsMedical databases were searched included PubMed, Web of Science, EBSCO and Google Scholar (up to December 7, 2022). Studies evaluating association between anticholinergic medication uses and the risk of pneumonia in elderly adults were included. Studies without available data were excluded. We made meta-analysis by using adjusted odds ratio (aOR) with 95% confidence intervals (CIs) from random-effects model. The risk of bias was assessed using ROBINS-I tool and statistical heterogeneity using the

resultsA total of six studies with 107,012 participants were included. Meta-analysis results showed that anticholinergic medication uses was related with an increased risk of pneumonia (aOR = 1.59; 95%CI, 1.32-1.92) and stroke-associated pneumonia (aOR = 2.02; 95%CI, 1.76-2.33). Moreover, risk estimates of pneumonia for high-potency anticholinergics (aOR = 1.96; 95%CI, 1.22-3.14) were higher than those for low-potency anticholinergics (aOR = 1.58; 95%CI, 1.27-1.97). And increased risk of pneumonia was associated with the anticholinergic medication uses within 30 days (aOR = 2.13; 95%CI, 1.33-3.43), within 90 days (aOR = 2.03; 95%CI, 1.26-3.26) and chronic use (aOR = 1.65; 95%CI, 1.09-2.51).

conclusionsThe risk of pneumonia is increased in elderly adults with anticholinergic medication, especially with higher-potency anticholinergic drugs and in the initiation phase of anticholinergic medication. Clinicians should monitor their use in older patients carefully, especially when the pneumonia-related signs and symptoms are identified.

Indexed as

Cholinergic AntagonistsPneumoniaAdultAgedBiasHumansCholinergic AntagonistsAnticholinergic medicationelderly adultsmeta-analysispneumoniasystematic review

Identifiers

PMID37190776
PMCPMC10190193
OpenAlexW4376641961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.