Evidence map›Paper›PMID 37190759›Full record

ArticleDialogues in clinical neuroscience2023

Connectome-based prediction of craving in gambling disorder and cocaine use disorder.

Stephanie Antons, Sarah W Yip, Cheryl M Lacadie, Javid Dadashkarimi, Dustin Scheinost, Matthias Brand, Marc N Potenza

Abstract read
In one paragraph

Article in Dialogues in clinical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Connectome-based encoding of subjective drug responses to acute oral methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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  6. Predicting individual incubation of opioid craving by whole-brain functional connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  18. Network state dynamics underpin craving in a transdiagnostic population.medRxiv : the preprint server for health sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie AntonsGeneral Psychology: Cognition and Center for Behavioral Addiction Research (CeBAR), University of Duisburg-Essen, Duisburg, Germany.ORCID 0000-0003-3187-968X
Sarah W YipDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Cheryl M LacadieDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Javid DadashkarimiDepartment of Computer Science, Yale University, New Haven, CT, USA.ORCID 0000-0002-1905-547X
Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6301-1167
Matthias BrandGeneral Psychology: Cognition and Center for Behavioral Addiction Research (CeBAR), University of Duisburg-Essen, Duisburg, Germany.ORCID 0000-0002-4831-9542
Marc N PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6323-1354

Funding

Connectome-based prediction and neurodevelopmental trajectories of alcohol phenotypes across developmentR01AA027553 · NIAAA · YALE UNIVERSITY · PI SCHEINOST, DUSTIN, YIP, SARAH · 2019 to 2022
$1.7M
fMRI of Craving in Addictions: Gender DifferencesR01DA019039 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2005 to 2009
$1.6M
Neural mechanisms of galantamine treatment for cocaine dependenceK01DA039299 · NIDA · YALE UNIVERSITY · PI YIP, SARAH · 2016 to 2020
$905k
Functional networks related to cocaine dependence and its treatment and relapseR01DA039136 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2016 to 2018
$754k
NIAAA NIH HHS R01 AA027553NIDA NIH HHS K01 DA039299NIDA NIH HHS R01 DA019039NIDA NIH HHS R01 DA039136
6 · The paper itself

Abstract

introductionCraving, involving intense and urgent desires to engage in specific behaviours, is a feature of addictions. Multiple studies implicate regions of salience/limbic networks and basal ganglia, fronto-parietal, medial frontal regions in craving in addictions. However, prior studies have not identified common neural networks that reliably predict craving across substance and behavioural addictions.

methodsFunctional magnetic resonance imaging during an audiovisual cue-reactivity task and connectome-based predictive modelling (CPM), a data-driven method for generating brain-behavioural models, were used to study individuals with cocaine-use disorder and gambling disorder. Functions of nodes and networks relevant to craving were identified and interpreted based on meta-analytic data.

resultsCraving was predicted by neural connectivity across disorders. The highest degree nodes were mostly located in the prefrontal cortex. Overall, the prediction model included complex networks including motor/sensory, fronto-parietal, and default-mode networks. The decoding revealed high functional associations with components of memory, valence ratings, physiological responses, and finger movement/motor imagery.

conclusionsCraving could be predicted across substance and behavioural addictions. The model may reflect general neural mechanisms of craving despite specificities of individual disorders. Prefrontal regions associated with working memory and autobiographical memory seem important in predicting craving. For further validation, the model should be tested in diverse samples and contexts.

Indexed as

CocaineConnectomeGamblingSubstance-Related DisordersBrainCravingHumansMagnetic Resonance ImagingCocaineaddictive behaviourscocaineCravingcue-reactivitygamblingmachine learning

Identifiers

PMID37190759
PMCPMC10190201

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.