ArticleBrain sciences2023
The Expression of Affective Temperaments in Cystic Fibrosis Patients: Psychopathological Associations and Possible Neurobiological Mechanisms.
Andrea Amerio, Luca Magnani, Carlo Castellani, Irene Schiavetti, Gabriele Sapia, Francesca Sibilla, Rita Pescini, Rosaria Casciaro, Federico Cresta, Andrea Escelsior and 5 more
Open access · goldAbstract read
In one paragraphArticle in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors at 4 institutions in 2 countries.
Andrea AmerioDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-3439-340X Luca MagnaniDepartment of Mental Health and Pathological Addictions, Genoa Local Health Authority, 16126 Genoa, Italy.ORCID 0000-0002-3620-2021 Carlo CastellaniCystic Fibrosis Center, IRCCS Istituto Giannina Gaslini-Ospedale Pediatrico, 16147 Genoa, Italy.ORCID 0000-0003-1916-0963 Irene SchiavettiDepartment of Health Sciences, Section of Biostatistics, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-5460-2977 Gabriele SapiaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Francesca SibillaIRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Rita PesciniCystic Fibrosis Center, IRCCS Istituto Giannina Gaslini-Ospedale Pediatrico, 16147 Genoa, Italy.
Rosaria CasciaroCystic Fibrosis Center, IRCCS Istituto Giannina Gaslini-Ospedale Pediatrico, 16147 Genoa, Italy.
Federico CrestaCystic Fibrosis Center, IRCCS Istituto Giannina Gaslini-Ospedale Pediatrico, 16147 Genoa, Italy.ORCID 0000-0002-2483-5374 Andrea EscelsiorDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Alessandra CostanzaDepartment of Psychiatry, Faculty of Medicine, Geneva University (UNIGE), 1211 Geneva, Switzerland.ORCID 0000-0001-6387-6462 Andrea AgugliaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-2003-2101 Gianluca SerafiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-6631-856X Mario AmoreDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
Riccardo CiprandiCystic Fibrosis Center, IRCCS Istituto Giannina Gaslini-Ospedale Pediatrico, 16147 Genoa, Italy.ORCID 0000-0002-2912-1792 Ospedale Policlinico San Martino · ITIstituto Giannina Gaslini · ITUniversity of Genoa · ITUniversity of Geneva · CH
Funding
Fondazione per la Ricerca sulla Fibrosi Cistica FFC#21/2021
6 · The paper itselfAbstract
The aim of this study was to investigate the association between Cystic Fibrosis (CF) and affective temperaments, considering the relevance of ionic balances in neural excitability, as a possible neurobiological basis for temperamental expression. A cross-sectional study involving 55 adult CF patients was conducted. Sociodemographic, clinical and therapeutic characteristics, temperamental and personality dispositions and depressive and anxiety symptoms were evaluated through standardized semi-structured and structured interviews. The majority of the enrolled CF patients were receiving Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) therapy (72.7%), and most of them had hyperthymic temperament predominance (29.1%). Different TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire) dimensions were not associated with the type of CF phenotype-related mutation or with the use of CFTR-modulator therapy. However, a tendency towards irritability was noted in patients not undergoing CFTR modulator therapy (6.7 ± 4.72 vs. 4.7 ± 4.33;
Indexed as
CFTR-modulator therapyCystic Fibrosistemperament
Identifiers
PMID37190584
PMCPMC10137099
OpenAlexW4362609157
What OpenQuestion holds
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LicenceCC BY
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