ArticleBrain sciences2023
The Comorbidity of Depression and Anxiety Symptoms in Tinnitus Sufferers: A Network Analysis.
Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Candidate Key Proteins in Thalamo-Amygdala Signaling in Tinnitus: A Bioinformatics Study.International journal of molecular sciences · 2026Article
- Psychiatric Comorbidity in Chronic Tinnitus: Depression and Anxiety in an Otolaryngology Outpatient Cohort.Neuropsychiatric disease and treatment · 2026Article
- Depression, anxiety, and sleep problems among Chinese university students enrolled in basketball elective courses: a network psychometric analysis.Frontiers in psychology · 2026Article
- Depressed mood as a transdiagnostic target relevant to anxiety and/or psychosis: a scoping review.BMJ open · 2025Article
- The network and interactive pattern of social adjustment and psychological symptoms in patients with spinal cord injury: a network analysis.BMC psychology · 2025Article
- When the Mind Meets the Ear: A Scoping Review on Tinnitus and Clinically Measured Psychiatric Comorbidities.Journal of clinical medicine · 2025Review
- Network analysis of anxiety and depressive symptoms among patients with cardiovascular disease.BMC public health · 2025Article
- A network analysis of the heterogeneity and associated risk and protective factors of depression and anxiety among college students.Scientific reports · 2025Article
- The comorbidity of anxiety and depression symptoms in obsessive-compulsive disorder: a network analysis.Frontiers in psychiatry · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
- Exploring the interaction between emotional states and tinnitus severity before and after a sound therapy intervention.Journal of otology · 2025Article
- Anxiety and depression in Chinese cataract patients: a network analysis.BMC psychology · 2024Article
- Network analysis of anxiety and depressive symptoms among patients with heart failure.BMC psychiatry · 2024Article
- Temporal network of experience sampling methodology identifies sleep disturbance as a central symptom in generalized anxiety disorder.BMC psychiatry · 2024Article
- Network analysis of depression and anxiety symptoms and their associations with life satisfaction among Chinese hypertensive older adults: a cross-sectional study.Frontiers in public health · 2024Article
- The impact of tinnitus on Dutch general practices: A retrospective study using routine healthcare data.PloS one · 2024Article
- Enhanced response and safety of combining dunhuang 'moxibustion classic' acupuncture with carbamazepine in treating neuropathic tinnitus and identifying risk factors affecting sleep quality.American journal of translational research · 2024Article
- Tinnitus, Suicide, and Suicidal Ideation: A Scoping Review of Primary Research.Brain sciences · 2023Article
- Neuroimaging Study of Brain Functional Differences in Generalized Anxiety Disorder and Depressive Disorder.Brain sciences · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSufferers of tinnitus, especially of the prolonged type, frequently suffer from comorbid depression and anxiety. From the perspective of the network model, this comorbidity is thought to be an interacting system of these two symptoms. In our study, we conducted a network analysis of depression and anxiety comorbidity in tinnitus sufferers, aiming to identify the central and bridge symptoms and make informed suggestions for clinical interventions and psychotherapy.
methodA total of 566 tinnitus sufferers were enrolled in our study. The Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder 7-Item Questionnaire (GAD-7) were selected to evaluate depression and anxiety symptoms, respectively, followed by network analysis to construct the interacting networks.
resultsThe findings identified six edges of strongest regularized partial correlations in this network. Of these, three were depression symptoms and three were anxiety symptoms. The anxiety symptoms "Unable to control worry" and "Relaxation difficulty" and the depression symptom "Feeling depressed or hopeless" had the highest expected influence centrality. The analysis results also revealed three bridge symptoms: "Afraid something awful might happen", "Feeling of worthlessness", and "Trouble concentrating". As for "Suicidal ideation", the direct relations between this symptom and "Afraid something awful might happen" and "Feeling depressed or hopeless" were the strongest.
conclusionsThe central and bridge symptoms of the interacting network of depression and anxiety symptoms in tinnitus sufferers can be considered a significant transdiagnostic intervention target for the management of this comorbidity. In particular, clinical prevention and psychotherapy should be implemented, targeting the symptoms that have the strongest associations with suicidal ideation.
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