Evidence map›Paper›PMID 37190539›Full record

ArticleBrain sciences2023

Effects on Corticospinal Tract Homology of Faremus Personalized Neuromodulation Relieving Fatigue in Multiple Sclerosis: A Proof-of-Concept Study.

Massimo Bertoli, Angela Tataranni, Susanna Porziani, Patrizio Pasqualetti, Eugenia Gianni, Joy Grifoni, Teresa L'Abbate, Karolina Armonaite, Livio Conti, Andrea Cancelli and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07567989 (Effectiveness of a Home-Based Therapeutic Exercise Program and Transcranial Direct Current Stimulation), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07567989 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Effectiveness of a Home-Based Therapeutic Exercise Program and Transcranial Direct Current Stimulation (tDCS) as a Treatment for Fatigue in Patients With Multiple Sclerosis

TypeinterventionalSponsorJacobo FormigoRan2025 to 2026Enrolled60ConditionsMultiple SclerosisArmsHome-Based Therapeutic Exercise Program, Transcranial Direct Current Stimulation, Sham tDCS
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Massimo BertoliLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.ORCID 0000-0002-6742-8891
Angela TataranniLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Susanna PorzianiLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.ORCID 0009-0008-7487-0240
Patrizio PasqualettiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5560-1979
Eugenia GianniLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Joy GrifoniLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Teresa L'AbbateLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Karolina ArmonaiteLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Livio ContiEngineering Faculty, International Telematic University Uninettuno, 00186 Rome, Italy.ORCID 0000-0003-2966-2000
Andrea CancelliLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Carlo CottoneLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Franco MarinozziDepartment of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, 00185 Rome, Italy.
Fabiano BiniDepartment of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5641-1189
Federico CecconiLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.
Franca TecchioLaboratory of Electrophysiology for Translational neuroScience (LET'S), Laboratory of Agent-Based Social Simulation (LABSS), Italian National Research Council (CNR), Via Palestro 32, 00185 Rome, Italy.ORCID 0000-0002-1325-5059
National Research Council · ITSapienza University of Rome · ITUniversity of Chieti-Pescara · ITIstituto Nazionale di Fisica Nucleare, Roma Tor Vergata · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFatigue in multiple sclerosis (MS) is a frequent and invalidating symptom, which can be relieved by non-invasive neuromodulation, which presents only negligible side effects. A 5-day transcranial direct-current stimulation, 15 min per day, anodically targeting the somatosensory representation of the whole body against a larger occipital cathode was efficacious against MS fatigue (fatigue relief in multiple sclerosis, Faremus treatment). The present proof-of-concept study tested the working hypothesis that Faremus S1 neuromodulation modifies the homology of the dominant and non-dominant corticospinal (CST) circuit recruitment.

methodsCST homology was assessed via the Fréchet distance between the morphologies of motor potentials (MEPs) evoked by transcranial magnetic stimulation in the homologous left- and right-hand muscles of 10 fatigued MS patients before and after Faremus.

resultsIn the absence of any change in MEP features either as differences between the two body sides or as an effect of the treatment, Faremus changed in physiological direction the CST's homology. Faremus effects on homology were more evident than recruitment changes within the dominant and non-dominant sides.

conclusionsThe Faremus-related CST changes extend the relevance of the balance between hemispheric homologs to the homology between body sides. With this work, we contribute to the development of new network-sensitive measures that can provide new insights into the mechanisms of neuronal functional patterning underlying relevant symptoms.

Indexed as

corticospinal tractmultiple sclerosis (MS)precision medicinetranscranial direct-current stimulation (tDCS)transcranial electric stimulation (tES)transcranial magnetic stimulation (TMS)

Identifiers

PMID37190539
PMCPMC10136421
OpenAlexW4361284598

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.