Evidence map›Paper›PMID 37190322›Full record

ArticleCancers2023

Characterization of Tumor and Immune Tumor Microenvironment of Primary Tumors and Metastatic Sites in Advanced Renal Cell Carcinoma Patients Based on Response to Nivolumab Immunotherapy: Preliminary Results from the Meet-URO 18 Study.

Sara Elena Rebuzzi, Matteo Brunelli, Francesca Galuppini, Valerio Gaetano Vellone, Alessio Signori, Fabio Catalano, Alessandra Damassi, Gabriele Gaggero, Pasquale Rescigno, Marco Maruzzo and 16 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sara Elena RebuzziMedical Oncology Unit, Ospedale San Paolo, 17100 Savona, Italy.ORCID 0000-0003-0546-6304
Matteo BrunelliPathology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, 37124 Verona, Italy.
Francesca GaluppiniSurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35128 Padua, Italy.ORCID 0000-0002-3245-2322
Valerio Gaetano VellonePathology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-5107-1584
Alessio SignoriDepartment of Health Sciences (DISSAL), Section of Biostatistics, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-6289-9144
Fabio CatalanoMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0001-5002-9782
Alessandra DamassiMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Gabriele GaggeroPathology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Pasquale RescignoCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.
Marco MaruzzoOncology Unit 1, Istituto Oncologico Veneto IOV-IRCCS, 35128 Padua, Italy.
Sara MerlerSection of Oncology, Department of Medicine, University of Verona and Verona University Hospital Trust, 37134 Verona, Italy.ORCID 0000-0002-8691-6284
Francesca VignaniDivision of Medical Oncology, Ordine Mauriziano Hospital, 10128 Turin, Italy.
Alessia CavoOncology Unit, Villa Scassi Hospital, 16149 Genoa, Italy.
Umberto BassoOncology Unit 1, Istituto Oncologico Veneto IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-5075-2177
Michele MilellaSection of Oncology, Department of Medicine, University of Verona and Verona University Hospital Trust, 37134 Verona, Italy.
Olimpia PanepintoDivision of Medical Oncology, Ordine Mauriziano Hospital, 10128 Turin, Italy.
Manlio MencoboniOncology Unit, Villa Scassi Hospital, 16149 Genoa, Italy.
Marta SbaragliaSurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35128 Padua, Italy.
Angelo Paolo Dei TosSurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35128 Padua, Italy.
Veronica MurianniMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0002-4955-0295
Malvina CremanteMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0002-4778-0038
Miguel Angel Llaja ObispoMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Michele MaffezzoliDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Giuseppe Luigi BannaDepartment of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth PO6 3LY, UK.ORCID 0000-0003-0764-3650
Sebastiano ButiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0003-0876-0226
Giuseppe FornariniMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0003-4754-6572

Funding

Lega Italiana per la Lotta ai Tumori Bando 5 x 1000 LILT 2019
6 · The paper itself

Abstract

backgroundPrognostic and predictive factors for patients with metastatic renal cell carcinoma (mRCC) treated with immunotherapy are highly warranted, and the immune tumor microenvironment (I-TME) is under investigation.

methodsThe Meet-URO 18 was a multicentric retrospective study assessing the I-TME in mRCC patients treated with ≥2nd-line nivolumab, dichotomized into

resultsA total of 116 tumor tissue samples from 84 patients (59% were primary tumors and 41% were metastases) were evaluated. Samples from

conclusionsDifferential IHC patterns between the tumors in patients who were

Indexed as

CD56immune checkpoint inhibitorimmune infiltrationimmunohistochemistryimmunotherapylymphocytenivolumabrenal cell carcinomatumor microenvironment

Identifiers

PMID37190322
PMCPMC10136746

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.