Evidence map›Paper›PMID 37190300›Full record

ArticleCancers2023

Hashimoto's Thyroiditis: A Protective Factor against Recurrence in BRAF-Wild Type Differentiated Thyroid Carcinoma.

Peter P Issa, Mahmoud Omar, Yusef Buti, Mohamed Aboueisha, Ruhul Munshi, Mohammad Hussein, Muhib Haidari, Graham Blair, Chad P Issa, Mohamed Shama and 2 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Peter P IssaDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-5248-3142
Mahmoud OmarDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Yusef ButiDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Mohamed AboueishaDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Ruhul MunshiDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Mohammad HusseinDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Muhib HaidariSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-7003-034X
Graham BlairSchool of Medicine, Tulane University, New Orleans, LA 70112, USA.
Chad P IssaSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Mohamed ShamaDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Eman ToraihDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-9267-3787
Emad KandilDepartment of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.

Funding

American Thyroid Association THYROIDGRANT2021-0000000232Tulane University School of Medicine Pilot GrantTulane University Tulane University Bridge Fund
6 · The paper itself

Abstract

A recent work analyzing the concomitant factors BRAF mutation (risk factor) and Hashimoto's thyroiditis (HT) (protective factor) found that the presence of HT reduced lymph node metastasis in BRAF-mutated papillary thyroid carcinoma. Whether this notion is upheld with respect to disease recurrence and differentiated thyroid carcinoma (DTC), however, is unknown. We aimed to investigate the effect of underlying HT in DTC patients and its influence on recurrence with a specific emphasis in BRAF-mutated tumors. A total of 469 patients were included. Patients were stratified according to BRAF and HT status. Multivariate regression analysis was conducted to determine protective and risk factors of disease recurrence in patients with DTC. HT was associated with less-aggressive carcinomas including more frequent microcarcinomas (HT: 45.0% vs. no-HT: 34.0%,

Indexed as

Hashimoto’s thyroiditisprotective factorrecurrencerisk factorthyroid cancer

Identifiers

PMID37190300
PMCPMC10137168

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.