Evidence map›Paper›PMID 37190264›Full record

ArticleCancers2023

Classifying Malignancy in Prostate Glandular Structures from Biopsy Scans with Deep Learning.

Ryan Fogarty, Dmitry Goldgof, Lawrence Hall, Alex Lopez, Joseph Johnson, Manoj Gadara, Radka Stoyanova, Sanoj Punnen, Alan Pollack, Julio Pow-Sang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ryan FogartyDepartment of Machine Learning, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-2468-510X
Dmitry GoldgofDepartment of Computer Science and Engineering, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0001-5461-863X
Lawrence HallDepartment of Computer Science and Engineering, University of South Florida, Tampa, FL 33620, USA.
Alex LopezTissue Core Facility, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Joseph JohnsonAnalytic Microscopy Core Facility, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Manoj GadaraAnatomic Pathology Division, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Radka StoyanovaDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Sanoj PunnenDesai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Alan PollackDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Julio Pow-SangGenitourinary Cancers, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Yoganand BalagurunathanDepartment of Machine Learning, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-5598-4727
Moffitt Cancer Center · USUniversity of Miami · USUniversity of South Florida · US

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
UM Calabresi Clinical Oncology Research Career Development AwardK12CA226330 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Alan Pollack · 2018 to 2026
$5.1M
MRI Imaging and Genetic Signatures to Manage Prostate Cancer OverdiagnosisR01CA189295 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI POLLACK, ALAN · 2014 to 2018
$3.2M
MRI Imaging and Biomarkers for Early Detection of Aggressive Prostate CancerU01CA239141 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI POLLACK, ALAN, PUNNEN, SANOJ · 2019 to 2023
$3.0M
(PQC4) Habitats in Prostate CancerR01CA190105 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BALAGURUNATHAN, YOGANAND, GILLIES, ROBERT J. · 2014 to 2017
$2.8M
NCI NIH HHS K12 CA226330NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA189295NCI NIH HHS R01 CA190105NCI NIH HHS U01 CA200464NCI NIH HHS U01 CA239141
6 · The paper itself

Abstract

Histopathological classification in prostate cancer remains a challenge with high dependence on the expert practitioner. We develop a deep learning (DL) model to identify the most prominent Gleason pattern in a highly curated data cohort and validate it on an independent dataset. The histology images are partitioned in tiles (14,509) and are curated by an expert to identify individual glandular structures with assigned primary Gleason pattern grades. We use transfer learning and fine-tuning approaches to compare several deep neural network architectures that are trained on a corpus of camera images (ImageNet) and tuned with histology examples to be context appropriate for histopathological discrimination with small samples. In our study, the best DL network is able to discriminate cancer grade (GS3/4) from benign with an accuracy of 91%, F

Indexed as

convolutional neural networkdeep learningGleason cancer gradingGleason scoreISUP gradepathologyprostatetransfer learninguropathologywhole-slide image

Identifiers

PMID37190264
PMCPMC10136774
OpenAlexW4366184892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.