Evidence map›Paper›PMID 37190137›Full record

ArticleCancers2023

Prediction of Deep Myometrial Infiltration, Clinical Risk Category, Histological Type, and Lymphovascular Space Invasion in Women with Endometrial Cancer Based on Clinical and T2-Weighted MRI Radiomic Features.

Xingfeng Li, Michele Dessi, Diana Marcus, James Russell, Eric O Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xingfeng LiDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.ORCID 0000-0002-6640-1048
Michele DessiDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Diana MarcusDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.ORCID 0000-0001-9918-1996
James RussellThe Imaging Department, Imperial College Healthcare NHS Trust, UK Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.ORCID 0000-0003-0405-7058
Eric O AboagyeDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.ORCID 0000-0003-2276-6771
Laura Burney EllisDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Alexander SheekaThe Imaging Department, Imperial College Healthcare NHS Trust, UK Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.ORCID 0000-0002-2176-0661
Won-Ho Edward ParkThe Imaging Department, Imperial College Healthcare NHS Trust, UK Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.
Nishat BharwaniDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.ORCID 0000-0002-6236-1480
Sadaf Ghaem-MaghamiDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.ORCID 0000-0002-7369-5080
Andrea G RockallDepartment of Surgery and Cancer, Imperial College Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Hammersmith Hospital · GBImperial College Healthcare NHS Trust · GB

Funding

Imperial National Institute for Health Research (NIHR) Biomedical Research Centre, Imperial CRUK Centre and Experimental Cancer Medicines Centre NoNumber
6 · The paper itself

Abstract

purposeTo predict deep myometrial infiltration (DMI), clinical risk category, histological type, and lymphovascular space invasion (LVSI) in women with endometrial cancer using machine learning classification methods based on clinical and image signatures from T2-weighted MR images.

methodsA training dataset containing 413 patients and an independent testing dataset consisting of 82 cases were employed in this retrospective study. Manual segmentation of the whole tumor volume on sagittal T2-weighted MRI was performed. Clinical and radiomic features were extracted to predict: (i) DMI of endometrial cancer patients, (ii) endometrial cancer clinical high-risk level, (iii) histological subtype of tumor, and (iv) presence of LVSI. A classification model with different automatically selected hyperparameter values was created. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve, F1 score, average recall, and average precision were calculated to evaluate different models.

resultsBased on the independent external testing dataset, the AUCs for DMI, high-risk endometrial cancer, endometrial histological type, and LVSI classification were 0.79, 0.82, 0.91, and 0.85, respectively. The corresponding 95% confidence intervals (CI) of the AUCs were [0.69, 0.89], [0.75, 0.91], [0.83, 0.97], and [0.77, 0.93], respectively.

conclusionIt is possible to classify endometrial cancer DMI, risk, histology type, and LVSI using different machine learning methods.

Indexed as

clinical risk scoredeep myometrial infiltrationendometrial cancerfeature selectionhistological typelymphovascular space invasionmachine learning classificationradiomicsT2-weighted MRI

Identifiers

PMID37190137
PMCPMC10136642
OpenAlexW4363674382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.