Evidence map›Paper›PMID 37190099›Full record

ArticleCells2023

Improving Schwann Cell Differentiation from Human Adipose Stem Cells with Metabolic Glycoengineering.

Jian Du, Zihui Wang, Xiao Liu, Cecilia Hu, Kevin J Yarema, Xiaofeng Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Combinatorial expression of glial transcription factors induces Schwann cell-specific gene expression in mouse embryonic fibroblasts.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jian DuDepartment of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MST 823, Baltimore, MD 21201, USA.ORCID 0000-0001-7154-8987
Zihui WangDepartment of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MST 823, Baltimore, MD 21201, USA.
Xiao LiuDepartment of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MST 823, Baltimore, MD 21201, USA.
Cecilia HuDepartment of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MST 823, Baltimore, MD 21201, USA.
Kevin J YaremaDepartment of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Xiaofeng JiaDepartment of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MST 823, Baltimore, MD 21201, USA.ORCID 0000-0003-1445-8525
University of Maryland, Baltimore · USJohns Hopkins University · US

Funding

Stem Cell Surface Modification to Promote Nerve RegenerationR01NS117102 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Xiaofeng Jia · 2021 to 2026
$2.0M
Improving Brain Recovery Through GlycoengineeringR01NS125232 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Xiaofeng Jia · 2022 to 2026
$2.0M
Brain Recovery after Cardiac Arrest with Metabolic Glycoengineered Stem CellsR01NS110387 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JIA, XIAOFENG · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS110387NINDS NIH HHS R01NS110387NINDS NIH HHS R01 NS117102NINDS NIH HHS R01NS117102NINDS NIH HHS R01 NS125232NINDS NIH HHS R01NS125232
6 · The paper itself

Abstract

Schwann cells (SCs) are myelinating cells that promote peripheral nerve regeneration. When nerve lesions form, SCs are destroyed, ultimately hindering nerve repair. The difficulty in treating nerve repair is exacerbated due to SC's limited and slow expansion capacity. Therapeutic use of adipose-derived stem cells (ASCs) is emerging in combating peripheral nerve injury due to these cells' SC differentiation capability and can be harvested easily in large numbers. Despite ASC's therapeutic potential, their transdifferentiation period typically takes more than two weeks. In this study, we demonstrate that metabolic glycoengineering (MGE) technology enhances ASC differentiation into SCs. Specifically, the sugar analog Ac

Indexed as

AdipocytesSchwann CellsCell DifferentiationHumansPeripheral NervesStem Cellscell differentiationhuman adipose stem cellsmetabolic glycoengineeringnerve regenerationSchwann cell

Identifiers

PMID37190099
PMCPMC10136940
OpenAlexW4366547810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.