Evidence map›Paper›PMID 37190038›Full record

ArticleCells2023

Change in Eosinophil Count in Patients with Heart Failure Treated with Anakinra.

Michele Golino, Francesco Moroni, Marco Giuseppe Del Buono, Justin M Canada, Azita H Talasaz, Sebastian Piñel, James Mbualungu, Alessandra Vecchiè, Ai-Chen Jane Ho, Georgia K Thomas and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. IL-1 Blockade to Resolve Persistent Inflammation After STEMI.JACC. Basic to translational science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Michele GolinoPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0003-0141-0127
Francesco MoroniPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
Marco Giuseppe Del BuonoDepartment of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-7483-6164
Justin M CanadaPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0002-1342-7463
Azita H TalasazPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0003-1839-3685
Sebastian PiñelPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
James MbualunguRobert M. Berne Cardiovascular Research Center, Division of Cardiology-Heart and Vascular Center, University of Virginia, Charlottesville, VA 22904, USA.
Alessandra VecchièMedicina Generale 1, Medical Center, Department of Internal Medicine, Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi, 21100 Varese, Italy.ORCID 0000-0003-0410-5996
Ai-Chen Jane HoDepartment of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.
Georgia K ThomasPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0002-8303-258X
Salvatore CarbonePauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0002-8163-0527
Hayley E BillingsleyPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
Jeremy TurlingtonPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
Roshanak MarkleyPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
Cory TranklePauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
Roberto De PontiDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-3278-1721
Benjamin Van TassellPauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0003-0688-4487
Antonio AbbatePauley Heart Center, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0002-1930-785X
Virginia Commonwealth University · USUniversity of Insubria · ITAgostino Gemelli University Polyclinic · ITNotre Dame of Maryland University · USOspedale di Circolo e Fondazione Macchi · ITUniversity of Virginia · US

Funding

ZONISMIDE IN THE TREATMENT OF SEIZURES IN PATIENTSM01RR000058 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI BROUSSEAU, DAVID C · 1985 to 2006
$19.9M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031990 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI CLORE, JOHN N. · 2010 to 2011
$7.7M
Center for Clinical and Translational ResearchKL2RR031989 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI CLORE, JOHN N. · 2010 to 2011
$995k
Interleukin-1 blockade in heart failure with preserved ejection fractionR34HL118348 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ABBATE, ANTONIO, VAN TASSELL, BENJAMIN W · 2014 to 2015
$681k
Interleukin-1 blockade in recently decompensated heart failureR34HL117026 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ABBATE, ANTONIO, VAN TASSELL, BENJAMIN W · 2013 to 2014
$671k
The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.K23HL159270 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Justin McNair Canada · 2023 to 2026
$596k
NCATS NIH HHS UL1 TR000058NCRR NIH HHS KL2 RR031989NCRR NIH HHS KL2RR031989NCRR NIH HHS UL1 RR031990NCRR NIH HHS UL1TR000058NHLBI NIH HHS 1R34HL117026NHLBI NIH HHS 1R34HL118348NHLBI NIH HHS K23 HL159270NHLBI NIH HHS R34 HL117026NHLBI NIH HHS R34 HL118348
6 · The paper itself

Abstract

backgroundInterleukin-1 blockade with anakinra leads to a transient increase in eosinophil blood count (eosinophils) in patients with acute myocardial infarction. We aimed to investigate the effect of anakinra on changes in eosinophils in patients with heart failure (HF) and their correlation with cardiorespiratory fitness (CRF).

methodsWe measured eosinophils in 64 patients with HF (50% females), 55 (51-63) years of age, before and after treatment, and, in a subset of 41 patients, also after treatment cessation. We also evaluated CRF, measuring peak oxygen consumption (VO

resultsTreatment with anakinra significantly and transiently increased eosinophils, from 0.2 [0.1-0.3] to 0.3 [0.1-0.4] × 10

conclusionPatients with HF treated with anakinra experience a transient increase in eosinophils, which is associated with ISR and a greater improvement in peak VO

Indexed as

Cardiorespiratory FitnessHeart FailureEosinophilsExercise TestFemaleHumansInterleukin 1 Receptor Antagonist ProteinMaleInterleukin 1 Receptor Antagonist Proteincardiorespiratory fitnesseosinophilsexercise testheart failureinjection site reactioninterleukin-1interleukin-1 receptor antagonist protein

Identifiers

PMID37190038
PMCPMC10137267
OpenAlexW4365142333

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.