Evidence map›Paper›PMID 37190025›Full record

ArticleCells2023

Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer's Disease.

Ian Steinke, Manoj Govindarajulu, Priyanka Das Pinky, Jenna Bloemer, Sieun Yoo, Tracey Ward, Taylor Schaedig, Taylor Young, Fajar Setyo Wibowo, Vishnu Suppiramaniam and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ian SteinkeDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Manoj GovindarajuluDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.ORCID 0000-0003-4739-648X
Priyanka Das PinkyDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Jenna BloemerDepartment of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY 10027, USA.
Sieun YooDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Tracey WardDepartment of Pharmaceutical Sciences, Ferris State University, Big Rapids, MI 49307, USA.ORCID 0000-0002-1338-8986
Taylor SchaedigDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Taylor YoungDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Fajar Setyo WibowoDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Vishnu SuppiramaniamDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Rajesh H AminDepartment of Drug Discovery and Development, Auburn University, Auburn, AL 36879, USA.
Auburn University · USFerris State University · USKennesaw State University · USTouro College · US

Funding

Evaluation of a dual PPAR agonist for treatment of Alzheimer's diseaseR42AG065069 · NIA · OLEOLIVE, INC. · PI CARDELLI, JAMES · 2022 to 2023
$2.7M
Evaluation of a selective PPAR-gamma agonist for treatment of Alzheimer’s DiseaseR43AG065069 · NIA · OLEOLIVE, INC. · PI CARDELLI, JAMES · 2019 to 2020
$450k
Novel PPAR-gamma agonist selectively activate the ligand binding domain of PPAR-gamma and improve pathology and memory deficits in a 3xTg-Ad mouse model.R15AG048643 · NIA · AUBURN UNIVERSITY AT AUBURN · PI AMIN, RAJESH H, SUPPIRAMANIAM, VISHNU D · 2015 to 2015
$362k
NIA NIH HHS 1R43AG065069-01NIA NIH HHS R15 AG048643NIA NIH HHS R42 AG065069NIA NIH HHS R43 AG065069NIH HHS NIH R42AG065069-03A1NIH HHS R15AG048643
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCognitionHumansInflammationPPAR gammaAmyloid beta-PeptidesPPAR gammaAlzheimer’s diseasebehavioral deficitsdendritic spinesin silico drug designneurodegenerationperoxisomal proliferator activating receptorsynaptic plasticity

Identifiers

PMID37190025
PMCPMC10136457
OpenAlexW4363678948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.