Evidence map›Paper›PMID 37189841›Full record

ArticleBiomedicines2023

Identification of a NACC1-Regulated Gene Signature Implicated in the Features of Triple-Negative Breast Cancer.

Chrispus M Ngule, Hami Hemati, Xingcong Ren, Oluwafunminiyi Obaleye, Amos O Akinyemi, Felix F Oyelami, Xiaofang Xiong, Jianxun Song, Xia Liu, Jin-Ming Yang

Abstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Nucleus Accumbens Associated Protein 1 in Cancers-The Real Value.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Case report: A novelFrontiers in psychiatry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chrispus M NguleDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0009-0005-4838-0684
Hami HematiDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0001-6436-5111
Xingcong RenDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Oluwafunminiyi ObaleyeDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0001-6241-0652
Amos O AkinyemiDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0001-8074-8454
Felix F OyelamiDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Xiaofang XiongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Jianxun SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-9734-6176
Xia LiuDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Jin-Ming YangDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-8703-0493

Funding

University of Kentucky Center for Cancer MetabolismP20GM121327 · NIGMS · UNIVERSITY OF KENTUCKY · PI Binhua P Zhou · 2017 to 2026
$25.0M
Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyR01CA221867 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2018 to 2023
$2.8M
NCI NIH HHS R01 CA221867NIGMS NIH HHS P20 GM121327NIH HHS P20GM121327NIH HHS R01CA221867
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC), characterized by a deficiency in estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER2), is among the most lethal subtypes of breast cancer (BC). Nevertheless, the molecular determinants that contribute to its malignant phenotypes such as tumor heterogeneity and therapy resistance, remain elusive. In this study, we sought to identify the stemness-associated genes involved in TNBC progression. Using bioinformatics approaches, we found 55 up- and 9 downregulated genes in TNBC. Out of the 55 upregulated genes, a 5 gene-signature (

Indexed as

cancer stem cellsgene signatureNACC1triple-negative breast cancertumor progression

Identifiers

PMID37189841
PMCPMC10136325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.