ReviewBiomedicines2023
A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia.
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Neurobiological Contributions to Pain in Patients With Fibromyalgia
Determination of the Effect of Fermented Grape Juice Consumption on Oxidative Stress and Inflammation Biomarkers and SIRT-1 Levels in Fibromyalgia Patients
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effect of photobiomodulation on pain and quality of life in fibromyalgia syndrome: a systematic review.Lasers in medical science · 2026Pooled it
- Prenatal Stress, Enteric Nervous System Development, and the Microbiota-Gut-Brain Axis: A Hypothesis-Generating Framework for Irritable Bowel Syndrome and Fibromyalgia.International journal of molecular sciences · 2026Review
- The Neutrophil-to-Lymphocyte Ratio in Fibromyalgia: A Systematic Review with a Neuroimmune Perspective.Brain sciences · 2026Review
- Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.Journal of clinical medicine · 2026Review
- Fibromyalgia: A Multifactorial Pain Disorder.International journal of molecular sciences · 2026Review
- The associations between age, familial occurrence of fibromyalgia, and symptom severity in fibromyalgia: a cross-sectional study from a Finnish health center.BMC rheumatology · 2026Article
- Non-Invasive Electrochemical Biosensors for Fibromyalgia: A Path Toward Objective Physiological Monitoring and Personalized Management.Sensors (Basel, Switzerland) · 2026Review
- The Relationship Between Pain and Depression in Fibromyalgia: Structural Equation Modeling and Network Analysis.International journal of environmental research and public health · 2026Article
- Review
- Moving Toward Objective Diagnosis in Fibromyalgia: Emerging Biomarkers and Digital Phenotyping Tools.Biomedicines · 2026Review
- Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
- In Search of Molecular Correlates of Fibromyalgia: The Quest for Objective Diagnosis and Effective Treatments.International journal of molecular sciences · 2025Review
- Fibromyalgia: are you a genetic/environmental disease?Pain reports · 2025Review
- Association of Genetic Variants, Such as the μ-Opioid Receptor 1 (Biomedicines · 2025Article
- Article
- Advances in Neurological Pain Management: Bridging Scientific Innovations and Clinical Practice.Cureus · 2025Review
- Review
- Management of Fibromyalgia: Novel Nutraceutical Therapies Beyond Traditional Pharmaceuticals.Nutrients · 2025Review
- A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This narrative review summarizes the current knowledge of the genetic and epigenetic contributions to the development of fibromyalgia (FM). Although there is no single gene that results in the development of FM, this study reveals that certain polymorphisms in genes involved in the catecholaminergic pathway, the serotonergic pathway, pain processing, oxidative stress, and inflammation may influence susceptibility to FM and the severity of its symptoms. Furthermore, epigenetic changes at the DNA level may lead to the development of FM. Likewise, microRNAs may impact the expression of certain proteins that lead to the worsening of FM-associated symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.