Evidence map›Paper›PMID 37189727›Full record

ArticleBiomedicines2023

Comorbidities and Malignancy among NAFLD Patients Compared to the General Population, A Nation-Based Study.

Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Alexander Fich, Daniela Munteanu, David Yardeni, Ohad Etzion

Abstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naim Abu-FrehaThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva 84101, Israel.ORCID 0000-0002-4844-3308
Bracha CohenSoroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Michal GordonSoroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Sarah WeissmannThe Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Alexander FichThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Daniela MunteanuThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva 84101, Israel.
David YardeniThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Ohad EtzionThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva 84101, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Aims: We aimed to investigate the frequency of comorbidities and malignancies among NAFLD patients compared to the general population. (2) Methods: A retrospective study included adult patients with a NAFLD diagnosis. A control group was matched for age and gender. Demographics, comorbidities, malignancies, and mortality were collected and compared. (3) Results: 211,955 NAFLD patients were analyzed in comparison to 452,012 matched general population controls. Significantly higher rates of diabetes mellitus (23.2% vs. 13.3%), obesity (58.8% vs. 27.8%), hypertension (57.2% vs. 39.9%), chronic ischemic heart disease (24.7% vs. 17.3%), and CVA (3.2% vs. 2.8%) were found among NAFLD patients. Patients with NAFLD had significantly higher rates of the following malignancies: prostate cancer (1.6% vs. 1.2%), breast cancer (2.6% vs. 1.9%), colorectal cancer (1.8% vs. 1.4%), uterine cancer (0.4 vs. 0.2%), kidney cancer (0.8% vs. 0.5%), but a lower rate of lung cancer (0.9% vs. 1.2%) and stomach cancer (0.3% vs. 0.4%). The all-cause mortality rate among NAFLD patients was significantly lower in comparison to the general population (10.8% vs. 14.7%,

Indexed as

comorbiditiesfatty liverIsraelmalignancymortality

Identifiers

PMID37189727
PMCPMC10136025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.