Evidence map›Paper›PMID 37189571›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Validation of a MALDI-TOF MS Method for SARS-CoV-2 Detection on the Bruker Biotyper and Nasopharyngeal Swabs: A Brazil-UK Collaborative Study.

Otávio A Lovison, Raminta Grigaitė, Fabiana C Z Volpato, Jason K Iles, Jon Lacey, Fabiano Barreto, Sai R Pandiri, Lisiane da Luz R Balzan, Vlademir V Cantarelli, Afonso Luis Barth and 2 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Otávio A LovisonLaboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0003-0950-1656
Raminta GrigaitėMap Sciences Ltd., The iLab, Priory Park, Bedford MK44 3RZ, UK.
Fabiana C Z VolpatoLaboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Jason K IlesMap Sciences Ltd., The iLab, Priory Park, Bedford MK44 3RZ, UK.
Jon LaceyMap Sciences Ltd., The iLab, Priory Park, Bedford MK44 3RZ, UK.
Fabiano BarretoLaboratório Federal de Defesa Agropecuária, Porto Alegre 91780-580, RS, Brazil.
Sai R PandiriMap Sciences Ltd., The iLab, Priory Park, Bedford MK44 3RZ, UK.
Lisiane da Luz R BalzanGrupo Exame, Diagnósticos da América S.A. (DASA), Novo Hamburgo 93310-002, RS, Brazil.
Vlademir V CantarelliDepartamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-8903-7269
Afonso Luis BarthLaboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Ray K IlesMap Sciences Ltd., The iLab, Priory Park, Bedford MK44 3RZ, UK.
Andreza F MartinsLaboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.ORCID 0000-0001-6227-1920

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul CHAMADA FAPERGS/MS/CNPq 08/2020 - PPSUSHospital de Clínicas de Porto Alegre 2020-0582
6 · The paper itself

Abstract

We developed a MALDI-TOF mass spectrometry method for the detection of the SARS-CoV-2 virus in saliva-gargle samples using Shimadzu MALDI-TOF mass spectrometers in the UK. This was validated in the USA to CLIA-LDT standards for asymptomatic infection detection remotely via sharing protocols, shipping key reagents, video conferencing, and data exchange. In Brazil, more so than in the UK and USA, there is a need to develop non-PCR-dependent, rapid, and affordable SARS-CoV-2 infection screening tests that also identify variant SARS-CoV-2 and other virus infections. In addition, travel restrictions necessitated remote collaboration with validation on the available clinical MALDI-TOF-the Bruker Biotyper (microflex

Indexed as

COVID-19diagnosticsepidemiologyMALDI-TOFmass spectrometrypopulation screeningproteomicsSARS-CoV-2viral screening

Identifiers

PMID37189571
PMCPMC10137699

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.