Evidence map›Paper›PMID 37189466›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Delineation of Grade II and III Gliomas Investigated by 7T MRI: An Inter-Observer Pilot Study.

Martin Prener, Giske Opheim, Helle Juhl Simonsen, Christina Malling Engelmann, Morten Ziebell, Jonathan Carlsen, Olaf B Paulson

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Martin PrenerNeurobiology Research Unit, Rigshospitalet Blegdamsvej, 2100 Copenhagen, Denmark.
Giske OpheimNeurobiology Research Unit, Rigshospitalet Blegdamsvej, 2100 Copenhagen, Denmark.
Helle Juhl SimonsenFunctional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Glostrup, 2600 Copenhagen, Denmark.
Christina Malling EngelmannDepartment of Neurosurgery, Rigshospitalet Blegdamsvej, 2100 Copenhagen, Denmark.
Morten ZiebellDepartment of Neurosurgery, Rigshospitalet Blegdamsvej, 2100 Copenhagen, Denmark.
Jonathan CarlsenDepartment of Radiology, Rigshospitalet Blegdamsvej, 2100 Copenhagen, Denmark.ORCID 0000-0002-6724-7281
Olaf B PaulsonNeurobiology Research Unit, Rigshospitalet Blegdamsvej, 2100 Copenhagen, Denmark.ORCID 0000-0001-7712-8596
Rigshospitalet · DKGlostrup Hospital · DKUniversity of Copenhagen · DK

Funding

Lundbeck Foundation No number was given
6 · The paper itself

Abstract

purposeDiffuse low-grade gliomas (DLGGs) are low-malignancy brain tumors originating from the glial cells of the brain growing continuously and infiltratively along the neural axons and infiltrating the surrounding brain tissue. DLGGs usually transform into higher malignancy, causing progressive disability and premature death. MRI scans are valuable when assessing soft tissue abnormalities, but, due to the infiltrative properties of DLGGs, delineating the tumor borders is a challenging task. Therefore, the aim of this study was to explore the difference in gross tumor volume (GTV) of DLGGs delineated from 7 Tesla and 3 Tesla MRI scans.

methodPatients were recruited at the department of neurosurgery and were scanned in both a 7T and a 3T MRI scanner prior to the operation. Two observers delineated the tumors using semi-automatic delineation software. The results from each observer were blinded to the other observer's delineation.

resultsComparing GTVs from 7T and 3T, the percentage difference varied up to 40.4% on the T2-weighted images. The percentage difference in GTV varied up to 15.3% on the fluid-attenuated inversion recovery (FLAIR) images. On the T2-weighted images, most cases varied by approximately 15%; on the FLAIR sequence, half of the cases varied by approximately 5% and the other half by approximately 15%. The overall inter-observer agreement was near perfect, with an intraclass correlation of 0.969. The intraclass correlation was better on the FLAIR sequence than on the T2 sequence.

conclusionOverall, the GTVs delineated from 7T images were smaller. The increase in field strength improved the inter-observer agreement only on the FLAIR sequence.

Indexed as

delineation of tumor borderlow-grade gliomasMRIultra-high fieldvolumetric analysis

Identifiers

PMID37189466
PMCPMC10137409
OpenAlexW4362699063

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.