SynthesisThe international journal of behavioral nutrition and physical activity2023
Association of soft drinks and 100% fruit juice consumption with risk of cancer: a systematic review and dose-response meta-analysis of prospective cohort studies.
Synthesis in The international journal of behavioral nutrition and physical activity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk.GeroScience · 2025Pooled it
- Risk factors for breast cancer: an umbrella review of observational cohort studies and causal relationship analysis.Frontiers in oncology · 2025Pooled it
- Sugar sweetened and artificially sweetened beverages, fruit and vegetable juices and cancer risk: a World Cancer Research Fund International Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.medRxiv : the preprint server for health sciences · 2026Article
- [Ecological analysis of the association between dietary factors and thyroid carcinoma incidence based on GBD 2021 data].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Article
- Plant-Based Diet Quality and Gastric Cancer Risk: A Case-Control Study in High-Risk Regions of Fujian Province, China.Food science & nutrition · 2026Article
- Whole Fruits Versus 100% Fruit Juice: Revisiting the Evidence and Its Implications for US Healthy Dietary Recommendations.Nutrition bulletin · 2025Review
- Unhealthy Behaviours and All-Cause Mortality Among People With Chronic Hepatitis B, With and Without Hepatitis Delta (ANRS CO22 HEPATHER).Journal of viral hepatitis · 2025Article
- Sweet beverages and the risk of colorectal cancer: the Norwegian Women and Cancer Study.BMC cancer · 2025Article
- Consumption of aspartame and risk of breast cancer in the Nurses' Health Studies.Journal of the National Cancer Institute · 2025Article
- The mediating roles of anthropo-metabolic biomarkers on the association between beverage consumption and breast cancer risk.Nutrition journal · 2025Article
- Behavioral risk factors in oncology patients: A matched case control study from Yemen.PloS one · 2025Article
- The association of artificial sweeteners intake and risk of cancer: an umbrella meta-analysis.Frontiers in medicine · 2025Review
- Association of sweetened beverage intake with incident risk of breast cancer: a prospective cohort study.Frontiers in nutrition · 2025Article
- Higher consumption of sugar-sweetened beverages is associated with an increased risk of endometrial cancer: a prospective cohort study of 92,777 women from the UK Biobank.Frontiers in public health · 2025Article
- Bread Consumption and Cancer Risk: Systematic Review and Meta-Analysis of Prospective Cohort Studies.Current developments in nutrition · 2024Review
- Modelling the potential impact of a tax on fruit juice in South Africa: implications for the primary prevention of type 2 diabetes and health financing.BMC nutrition · 2024Article
- Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population.Blood advances · 2024Article
- Pro-Inflammatory Food, Gut Microbiota, and Cardiovascular and Pancreatic Diseases.Biomolecules · 2024Review
- An Apple a Day Keeps the Doctor Away, but It May Not Be Worth the Squeeze.Journal of the American Heart Association · 2023Article
- Sugar sweetened beverages, natural fruit juices, and cancer: what we know and what still needs to be assessed.Frontiers in nutrition · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies of the associations between soft drinks and the risk of cancer showed inconsistent results. No previous published systematic reviews and meta-analysis has investigated a dose-response association between exposure dose and cancer risk or assessed the certainty of currently available evidence. Therefore, we aim to demonstrate the associations and assessed the certainty of the evidence to show our confidence in the associations.
methodsWe searched Embase, PubMed, Web of Science, and the Cochrane Library from inception to Jun 2022, to include relevant prospective cohort studies. We used a restricted cubic spline model to conduct a dose-response meta-analysis and calculated the absolute effect estimates to present the results. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of the evidence.
resultsForty-two articles including on 37 cohorts enrolled 4,518,547 participants were included. With low certainty evidence, increased consumption of sugar-sweetened beverages (SSBs) per 250 mL/day was significantly associated with a 17% greater risk of breast cancer, a 10% greater risk of colorectal cancer, a 30% greater risk of biliary tract cancer, and a 10% greater risk of prostate cancer; increased consumption of artificially sweetened beverages (ASBs)re per 250 mL/day was significantly associated with a 16% greater risk of leukemia; increased consumption of 100% fruit juice per 250 mL/day was significantly associated with a 31% greater risk of overall cancer, 22% greater risk of melanoma, 2% greater risk of squamous cell carcinoma, and 29% greater risk of thyroid cancer. The associations with other specific cancer were no significant. We found linear dose-response associations between consumption of SSBs and the risk of breast and kidney cancer, and between consumption of ASBs and 100% fruit juices and the risk of pancreatic cancer.
conclusionsAn increment in consumption of SSBs of 250 mL/day was positively associated with increased risk of breast, colorectal, and biliary tract cancer. Fruit juices consumption was also positively associated with the risk of overall cancer, thyroid cancer, and melanoma. The magnitude of absolute effects, however, was small and mainly based on low or very low certainty of evidence. The association of ASBs consumption with specific cancer risk was uncertain.
trial registrationPROSPERO: CRD42020152223.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.