Evidence map›Paper›PMID 37189085›Full record

ArticleBMC anesthesiology2023

Postoperative glucocorticoids in patients with acute type A aortic dissection (GLAD): study protocol for a prospective, single-center, randomized controlled trial.

Yi-Zhi Deng, Ming-Hao Luo, Jing-Chao Luo, Jia-Kun Li, Jia-Qi Chen, Yi-Jie Zhang, Jun-Yi Hou, Ying Su, Guo-Wei Tu, Zhe Luo

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04734418 (Evaluation of Remifentanil and Dexmedetomidine in Patients With Noninvasive Mechanical Ventilation Intolerance After Cardiac Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04734418 naunknown statusnot on this map

Evaluation of Remifentanil and Dexmedetomidine in Patients With Noninvasive Mechanical Ventilation Intolerance After Cardiac Surgery: a Multicenter, Prospective, Single-blind, Randomized Controlled Study

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2021 to 2023Enrolled178ConditionsNIV IntoleranceArmsRemifentanil, Dexmedetomidine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yi-Zhi Deng *Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Ming-Hao Luo *Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Jing-Chao Luo *Cardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jia-Kun LiShanghai Medical College, Fudan University, Shanghai, 200032, China.
Jia-Qi ChenShanghai Medical College, Fudan University, Shanghai, 200032, China.
Yi-Jie ZhangCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jun-Yi HouCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Ying SuCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Guo-Wei TuCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. tu.guowei@zs-hospital.sh.cn.
Zhe LuoCardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. luo.zhe@zs-hospital.sh.cn.
Fudan University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients receiving surgical treatment of acute type A Aortic Dissection (aTAAD) are common to suffer organ dysfunction in the intensive care unit due to overwhelming inflammation. Previous studies have revealed that glucocorticoids may reduce complications in certain patient groups, but evidence between postoperative glucocorticoids administration and improvement in organ dysfunction after aTAAD surgery are lacking.

methodsThis study will be an investigator-initiated, prospective, single-blind, randomized, single-center study. Subjects with confirmed diagnosis of aTAAD undergoing surgical treatment will be enrolled and 1:1 randomly assigned to receive either glucocorticoids or normal treatment. All patients in the glucocorticoids group will be given methylprednisolone intravenously for 3 days after enrollment. The primary endpoint will be the amplitude of variation of Sequential Organ Failure Assessment score on post-operative day 4 compared to baseline. DISCUSSION: The trial will explore the rationale for postoperative application of glucocorticoids in patients after aTAAD surgery.

trial registrationThis study has been registered on ClinicalTrials.gov (NCT04734418).

Indexed as

Aortic DissectionGlucocorticoidsHumansMultiple Organ FailureProspective StudiesRandomized Controlled Trials as TopicSingle-Blind MethodTreatment OutcomeGlucocorticoidsAcute type A aortic dissectionGlucocorticoidMethylprednisoloneOrgan dysfunction

Identifiers

PMID37189085
PMCPMC10184462
OpenAlexW4376610687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.