ArticleNature chemistry2023
Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Dual-parameter chiral detection at the single-particle level enabled by surface cosine waves.Science advances · 2026Article
- Chip-Scale Aligned Chiral Carbon Nanotubes Exhibiting Giant Second Harmonic Generation.ACS nano · 2026Article
- Temperature-Enhanced Coercive Field by Chiral Molecules.The journal of physical chemistry letters · 2026Article
- Chirality-Induced Orbital-Angular-Momentum Selectivity in Electron Transmission and Scattering.Journal of chemical theory and computation · 2026Article
- What Does It Take for an Organic Closed Shell Molecule to Become Magnetic?The journal of physical chemistry letters · 2025Review
- Real-Time Visualisation of Reaction Kinetics and Dynamics: Single-Molecule Insights into the Iminium-Catalysed Diels-Alder Reaction.Angewandte Chemie (International ed. in English) · 2025Article
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Role of Electron Spin, Chirality, and Charge Dynamics in Promoting the Persistence of Nascent Nucleic Acid-Peptide Complexes.The journal of physical chemistry. B · 2025Article
- Quasi-Continuous Efficient Regulation of Single-Molecule Electronic Distribution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Single-molecule junctions map the interplay between electrons and chirality.Nature communications · 2025Article
- Monitoring C-C coupling in catalytic reactions via machine-learned infrared spectroscopy.National science review · 2025Article
- Full on-device manipulation of olefin metathesis for precise manufacturing.Nature nanotechnology · 2025Article
- Questioning claims of monitoring the Michael addition reaction at the single-molecule level.Nature chemistry · 2024Article
- Reply to: Questioning claims of monitoring the Michael addition reaction at the single-molecule level.Nature chemistry · 2024Article
- Electrical monitoring of single-event protonation dynamics at the solid-liquid interface and its regulation by external mechanical forces.Nature communications · 2024Article
- A chemical perspective on the chiral induced spin selectivity effect.National science review · 2024Review
- Massive acceleration of SChemical science · 2024Article
- Technologies for investigating single-molecule chemical reactions.National science review · 2024Review
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Chiral Induced Spin Selectivity.Chemical reviews · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Stereochemistry has an essential role in organic synthesis, biological catalysis and physical processes. In situ chirality identification and asymmetric synthesis are non-trivial tasks, especially for single-molecule systems. However, going beyond the chiral characterization of a large number of molecules (which inevitably leads to ensemble averaging) is crucial for elucidating the different properties induced by the chiral nature of the molecules. Here we report direct monitoring of chirality variations during a Michael addition followed by proton transfer and keto-enol tautomerism in a single molecule. Taking advantage of the chirality-induced spin selectivity effect, continuous current measurements through a single-molecule junction revealed in situ chirality variations during the reaction. Chirality identification at a high sensitivity level provides a promising tool for the study of symmetry-breaking reactions and sheds light on the origin of the chirality-induced spin selectivity effect itself.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.