ArticleNature neuroscience2023
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07706335 (Insulin Resistance and Its Association With no Reflow Phenomenon After Primary PCI in Type II Diabetic STEMI Patients.), which is not on this map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insulin Resistance and Its Association With no Reflow Phenomenon After Primary PCI in Type II Diabetic STEMI Patients.
Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Integrative role of orexigenic peptides in neuroprotection and neurodegenerative disease modulation.Bioscience reports · 2026Review
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness.Neurobiology of sleep and circadian rhythms · 2026Review
- Behavior of neural networks in culture suggest that sporadic and genetic forms of Alzheimer's disease may not be equivalent.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Alzheimer's Pathology Enhances Excitatory Synaptic Input and Integration in VTA Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sleep and stress as modifiable drivers of Alzheimer's disease.NPJ dementia · 2026Review
- Tracing melanin-concentrating hormone function: decades of memory research and emerging links to Alzheimer's disease.Frontiers in neuroscience · 2026Review
- Sleep-Wake Transitions Are Impaired in thebioRxiv : the preprint server for biology · 2025Article
- Progress in Research on the Mechanism of GABA in Improving Sleep.Foods (Basel, Switzerland) · 2025Review
- Sleep in neurodegenerative diseases: A focus on melatonin, melanin-concentrating hormone and orexin.Journal of neuroendocrinology · 2025Review
- Autophagic impairment in sleep-wake circuitry is linked to sleep loss at the early stages of Alzheimer's disease.Molecular neurodegeneration · 2025Article
- PKC-dependent enhancement of glutamate input to VTA dopamine neurons in 3xTg-AD mice.bioRxiv : the preprint server for biology · 2025Article
- Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease.Nature communications · 2025Article
- Mechanisms of comorbidity between Alzheimer's disease and pain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Article
- Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson's disease.Frontiers in genetics · 2025Article
- Effects of mild cognitive impairment and sleep disorders on the minimum alveolar concentration value of sevoflurane.BMC anesthesiology · 2024Article
- Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1.Cell discovery · 2024Article
- Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits.Nature communications · 2024Article
- Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease.MedComm · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 7 institutions in 6 countries.
Sara CalafateVIB Center for Brain & Disease Research, Leuven, Belgium. sara.calafate@kuleuven.be.ORCID http://orcid.org/0000-0002-1276-3211
Gökhan ÖzturanVIB Center for Brain & Disease Research, Leuven, Belgium.
Nicola ThruppVIB Center for Brain & Disease Research, Leuven, Belgium.
Jeroen VanderlindenVIB Center for Brain & Disease Research, Leuven, Belgium.
Luísa Santa-MarinhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Rafaela Morais-RibeiroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Antonella RuggieroDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ivan BozicZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.
Thomas RusterholzZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.
Blanca Lorente-EcheverríaVIB Center for Brain & Disease Research, Leuven, Belgium.
Marcelo DiasLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID http://orcid.org/0000-0003-1844-8631
Wei-Ting ChenVIB Center for Brain & Disease Research, Leuven, Belgium.
Mark FiersVIB Center for Brain & Disease Research, Leuven, Belgium.
Ashley LuVIB Center for Brain & Disease Research, Leuven, Belgium.
Ine VlaeminckVIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8934-6179
Eline CreemersVIB Center for Brain & Disease Research, Leuven, Belgium.
Katleen CraessaertsVIB Center for Brain & Disease Research, Leuven, Belgium.
Joris VandenbemptVIB Center for Brain & Disease Research, Leuven, Belgium.
Luuk van BoekholdtVIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0001-5809-8379
Suresh PoovathingalVIB Center for Brain & Disease Research, Leuven, Belgium.
Kristofer DavieVIB Center for Brain & Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2182-1249
Dietmar Rudolf ThalDepartment of Imaging and Pathology, Laboratory of Neuropathology, and Leuven Brain Institute, KU-Leuven, O&N IV, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1036-1075
Keimpe WierdaVIB Center for Brain & Disease Research, Leuven, Belgium.
Tiago Gil OliveiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID http://orcid.org/0000-0003-0509-0562
Inna SlutskyDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0002-0700-2266
Antoine AdamantidisZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-2531-5175
Bart De StrooperVIB Center for Brain & Disease Research, Leuven, Belgium. bart.destrooper@kuleuven.be.ORCID http://orcid.org/0000-0001-5455-5819
Joris de WitVIB Center for Brain & Disease Research, Leuven, Belgium. joris.dewit@kuleuven.be.ORCID http://orcid.org/0000-0003-1120-1089
VIB-KU Leuven Center for Brain & Disease Research · BEUniversity of Minho · PTAllen Institute for Brain Science · USUniversity of Bern · CHTel Aviv University · ILUniversitair Ziekenhuis Leuven · BEVIB-KU Leuven Center for Microbiology · BE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased sleep quality. Here we show that homeostatic mechanisms transiently counteract the increased excitatory drive to CA1 neurons in App
Indexed as
Alzheimer DiseaseHypothalamic HormonesAnimalsMelaninsMiceMice, TransgenicNeuronsPituitary HormonesSleepHypothalamic Hormonesmelanin-concentrating hormoneMelaninsPituitary Hormones
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07706335ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.