ArticleScientific reports2023
Reproduction of human blood pressure waveform using physiology-based cardiovascular simulator.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Wearable Blood Pressure Monitoring Devices: Understanding Heterogeneity in Design and Evaluation.IEEE transactions on bio-medical engineering · 2024Pooled it
- Bench-to-Bedside Translation of Self-Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Research and development of the pulse acquisition system and the pulse biomimetic reproduction system.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Technological evolution ofFrontiers in physiology · 2025Review
- Feature extraction tool using temporal landmarks in arterial blood pressure and photoplethysmography waveforms.NPJ cardiovascular health · 2025Article
- Advancements in surgical education: exploring animal and simulation models in fetal and neonatal surgery training.Frontiers in pediatrics · 2024Review
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Authors and funding
5 authors.
Funding
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Abstract
This study presents a cardiovascular simulator that mimics the human cardiovascular system's physiological structure and properties to reproduce the human blood pressure waveform. Systolic, diastolic blood pressures, and its waveform are key indicators of cardiovascular health. The blood pressure waveform is closely related to the pulse wave velocity and the overlap of the forward and reflected pressure waves. The presented cardiovascular simulator includes an artificial aorta made of biomimetic silicone. The artificial aorta has the same shape and stiffness as the human standard and is encased with a compliance chamber. The compliance chamber prevents distortion of the blood pressure waveform from strain-softening by applying extravascular pressure. The blood pressure waveform reproduced by the simulator has a pressure range of 80-120 mmHg, a pulse wave velocity of 6.58 m/s, and an augmentation index of 13.3%. These values are in the middle of the human standard range, and the reproduced blood pressure waveform is similar to that of humans. The errors from the human standard values are less than 1 mmHg for blood pressure, 0.05 m/s for pulse wave velocity, and 3% for augmentation index. The changes in blood pressure waveform according to cardiovascular parameters, including heart rate, stroke volume, and peripheral resistance, were evaluated. The same pressure ranges and trends as in humans were observed for systolic and diastolic blood pressures according to cardiovascular parameters.
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