ReviewNature human behaviour2023
Maximizing the value of twin studies in health and behaviour.
Review in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic and environment influences on childhood victimization: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- "Yet the Problem Remains": Why Genetic Determinism Still Haunts Biomedical Research.Bioethics · 2026Article
- CircRNA profiles from one-tube multiplex probe-based qPCR can distinguish between monozygotic twins.International journal of legal medicine · 2026Article
- Heterogeneous Associations Between Objectively Measured Screen Time and Sleep in Early Adolescence.Technology, mind, and behavior · 2026Article
- Bidirectional causal association between cathepsins and neuropsychiatric disorders: univariate and multivariate Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- [Psychiatry as clinical neuroscience].Revista medica del Instituto Mexicano del Seguro Social · 2026Review
- Article
- The nature of depression and the biomedical model: ten questions in search of an answer.Translational psychiatry · 2026Review
- A multi-omics study on monozygotic twins discordant for amyotrophic lateral sclerosis and literature review underline a potential role for innate immunity and epigenetic dysregulation in disease mechanisms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Genetic underpinnings of chills from art and music.PLoS genetics · 2026Article
- Ethnic Discrimination Moderates Genetic Influences on Adolescent Internalizing and Externalizing Psychopathology.Behavior genetics · 2026Article
- An innovative diagnostic method for myopia using blood-based biomemristor.Materials today. Bio · 2025Article
- Utilising genomic association data for causal inference in anorexia nervosa.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Estimating the Genetic Risk of First-Degree Relatives for Chronic Diseases Using the Short Tandem Repeat Score as Model of Polygenic Inheritance.Biochemical genetics · 2025Article
- Mediating Role of Trauma Connecting Psychiatric Family History and Adolescent Mental Health.Biological psychiatry global open science · 2025Article
- Mental health-related genes that are sensitive to the environment.Nature human behaviour · 2025Article
- Distinct genetic underpinnings of inter-individual differences in the sensorimotor-association axis of cortical organisation.bioRxiv : the preprint server for biology · 2025Article
- Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood.Clinical epigenetics · 2025Article
- Twin modelling reveals partly distinct genetic pathways to music enjoyment.Nature communications · 2025Article
- Understanding Heritable Variation Among Hosts in Infectious Diseases Through the Lens of Twin Studies.Genes · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In the classical twin design, researchers compare trait resemblance in cohorts of identical and non-identical twins to understand how genetic and environmental factors correlate with resemblance in behaviour and other phenotypes. The twin design is also a valuable tool for studying causality, intergenerational transmission, and gene-environment correlation and interaction. Here we review recent developments in twin studies, recent results from twin studies of new phenotypes and recent insights into twinning. We ask whether the results of existing twin studies are representative of the general population and of global diversity, and we conclude that stronger efforts to increase representativeness are needed. We provide an updated overview of twin concordance and discordance for major diseases and mental disorders, which conveys a crucial message: genetic influences are not as deterministic as many believe. This has important implications for public understanding of genetic risk prediction tools, as the accuracy of genetic predictions can never exceed identical twin concordance rates.
Indexed as
Identifiers
37188734What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.