ArticleNature communications2023
Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 21 citations in OpenAlex.
- Cerebellar mitochondrial dysfunction coincides with structural and behavioral abnormalities in 3q29Del mice.bioRxiv : the preprint server for biology · 2026Article
- Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation.bioRxiv : the preprint server for biology · 2026Article
- Specialized outputs and behavioral contributions of Purkinje cell subtypes.bioRxiv : the preprint server for biology · 2026Article
- Region- and cell type-specific changes in gene expression in the cerebellum after classical fear conditioning.Communications biology · 2026Article
- Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation.bioRxiv : the preprint server for biology · 2026Article
- Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy.Brain : a journal of neurology · 2026Article
- Specific associations between heart rate variability and motor domains in children with attention-deficit/hyperactivity disorder: a comparative study.Frontiers in psychiatry · 2026Article
- Brain-wide mapping of developmental trajectories of cerebellar efferent projections.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21.Translational psychiatry · 2025Article
- Trisomy 21 Alters Motor Coordination, Vocal Communication, and Cerebellar Circuit Connectivity in the TcMAC21 Mouse.Research square · 2025Article
- The Nuclear Transitory Zone: A Key Player in the Cerebellar Development.Cerebellum (London, England) · 2025Review
- Sex dependent correlation of spleen atrophy and behavior deficits induced by binge treatment with ethanol in rodent models.NeuroImmune pharmacology and therapeutics · 2025Article
- Thalamic deep brain stimulation improves movement in a cerebellar model of lesion-based status dystonicus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity.Nature communications · 2025Article
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents.Cells · 2024Review
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
- Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity.bioRxiv : the preprint server for biology · 2024Article
- Targeting DBS to the centrolateral thalamic nucleus improves movement in a lesion-based model of acquired cerebellar dystonia in mice.bioRxiv : the preprint server for biology · 2024Article
- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We perturb cerebellar cortical or nuclei neuron function by eliminating glutamatergic neurotransmission during development, and then we measure motor and social behaviors in early postnatal and adult mice. Altering cortical and nuclei neurons impacts postnatal motor control and social vocalizations. Normalizing neurotransmission in cortical neurons but not nuclei neurons restores social behaviors while the motor deficits remain impaired in adults. In contrast, manipulating only a subset of nuclei neurons leaves social behaviors intact but leads to early motor deficits that are restored by adulthood. Our data uncover that glutamatergic neurotransmission from cerebellar cortical and nuclei neurons differentially control the acquisition of motor and social behaviors, and that the brain can compensate for some but not all perturbations to the developing cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.