Evidence map›Paper›PMID 37188699›Full record

ArticleBlood cancer journal2023

Conditional survival in multiple myeloma and impact of prognostic factors over time.

Nadine H Abdallah, Alexandra N Smith, Susan Geyer, Moritz Binder, Patricia T Greipp, Prashant Kapoor, Angela Dispenzieri, Morie A Gertz, Linda B Baughn, Martha Q Lacy and 10 more

Abstract read
In one paragraph

Article in Blood cancer journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nadine H AbdallahDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9195-1589
Alexandra N SmithDepartment of biostatistics, Mayo Clinic, Rochester, MN, USA.
Susan GeyerDepartment of biostatistics, Mayo Clinic, Rochester, MN, USA.
Moritz BinderDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9014-9658
Patricia T GreippDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5536-9011
Prashant KapoorDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4342-364X
Angela DispenzieriDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8780-9512
Morie A GertzDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3853-5196
Linda B BaughnDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5229-4897
Martha Q LacyDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Suzanne R HaymanDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Francis K BuadiDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3214-0203
David DingliDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7477-3004
Yi L HwaDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Yi LinDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-1556-6416
Taxiarchis KourelisDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8573-9434
Rahma WarsameDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Robert A KyleDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
S Vincent RajkumarDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5862-1833
Shaji K KumarDivision of Hematology, Mayo Clinic, Rochester, MN, USA. kumar.shaji@mayo.edu.ORCID 0000-0001-5392-9284

Funding

Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Rafael Fonseca · 2015 to 2026
$25.5M
NCI NIH HHS P50 CA186781
6 · The paper itself

Abstract

Overall survival estimates from diagnosis are valuable for guiding treatment, but do not consider the years already survived. Conditional survival (CS) provides dynamic survival predictions over time. This study was conducted to estimate CS at 1-8 years from diagnosis and the impact of baseline prognostic factors on CS in multiple myeloma (MM) patients. This is a retrospective study including 2556 MM patients diagnosed between 2004 and 2019. CS (t | s) was defined as the probability of surviving t years given survival of s years. Median age was 64 years. Median follow-up was 6.2 years and median overall survival from diagnosis was 7.5 years. The 5-year CS estimates at s = 0, 1, 2, 3, and 5 years were 0.64, 0.61, 0.61, 0.61, and 0.58, respectively. On multivariate analysis, age ≥ 65 and proteasome inhibitor+immunomodulatory-based induction were associated with decreased survival and increased survival, respectively, retained at 5 years. The adverse impact of 1q gain/amplification, high-risk IgH translocation, and ISS-3 was significant at 1 and 3 years but not 5 years. Chromosome 17 abnormality was associated with decreased survival only at 1 year. Among MM patients, 5-year CS was stable at 1-5 years from diagnosis. The prognostic impact of high-risk cytogenetic factors decreased with additional years survived.

Indexed as

Multiple MyelomaChild, PreschoolChromosome AberrationsHumansMiddle AgedPrognosisRetrospective StudiesRisk Factors

Identifiers

PMID37188699
PMCPMC10185675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.