Evidence map›Paper›PMID 37188665›Full record

ArticleNature communications2023

Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex.

Corey F Hryc, Venkata K P S Mallampalli, Evgeniy I Bovshik, Stavros Azinas, Guizhen Fan, Irina I Serysheva, Genevieve C Sparagna, Matthew L Baker, Eugenia Mileykovskaya, William Dowhan

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Sequential antibiotic exposure restores antibiotic susceptibility.The Journal of antimicrobial chemotherapy · 2025
    Article
  13. Capturing the native structure of membrane proteins using vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Flexibility and Hydration of the QJournal of chemical information and modeling · 2025
    Article
  15. Deciphering the language of mingling lipids and proteins.Current opinion in structural biology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Corey F HrycDepartment of Biochemistry and Molecular Biology, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.
Venkata K P S MallampalliDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.
Evgeniy I BovshikDepartment of Biochemistry and Molecular Biology, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.
Stavros AzinasDepartment of Biochemistry and Molecular Biology, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.ORCID 0000-0002-3744-9229
Guizhen FanDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.
Irina I SeryshevaDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.ORCID 0000-0001-6266-3422
Genevieve C SparagnaDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorada, USA.
Matthew L BakerDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA. matthew.l.baker@uth.tmc.edu.ORCID 0000-0001-9039-8523
Eugenia MileykovskayaDepartment of Biochemistry and Molecular Biology, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA. eugenia.Mileykovskaya@uth.tmc.edu.ORCID 0000-0002-8775-4467
William DowhanDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA. william.dowhan@uth.tmc.edu.ORCID 0000-0002-7252-3607
Imaging Center · USThe University of Texas Health Science Center · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Anschutz Medical Campus · US

Funding

PROJECT 5 - DUKE - STRUCTURE VALIDATION AND IMPROVEMENT FOR PROTEINS AND N. ACIDSP01GM063210 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI ADAMS, PAUL DAVID · 2001 to 2021
$33.5M
Structure-Function Studies Of IP3R ChannelsR01GM072804 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2005 to 2023
$4.8M
Regulation of glucose utilization by skeletal muscle SIK1R01DK092590 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2011 to 2021
$3.3M
ACQUISITION OF HIGH-THROUGHPUT 200 kV CRYO-TEMS10OD032204 · OD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SERYSHEVA, IRINA I · 2022 to 2022
$2.0M
The Role of Cardiolipin in Assembly and Function of the Mitochondrial RespirasomeR01GM115969 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DOWHAN, WILLIAM · 2017 to 2020
$1.8M
Mechanisms of inositol trisphosphate receptor-mediated calcium signalingR35GM153178 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Irina I Serysheva · 2024 to 2026
$1.7M
NIDDK NIH HHS R01 DK092590NIGMS NIH HHS P01 GM063210NIGMS NIH HHS R01 GM072804NIGMS NIH HHS R01 GM115969NIGMS NIH HHS R35 GM153178NIH HHS S10 OD032204
6 · The paper itself

Abstract

Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking. To address the essential role of cardiolipin in supercomplex organization, we report cryo-EM structures of a wild type supercomplex (IV

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCardiolipinsPhosphatidylglycerolsPhospholipidsCardiolipinsPhosphatidylglycerolsPhospholipidsSaccharomyces cerevisiae Proteins

Identifiers

PMID37188665
PMCPMC10185535
OpenAlexW4376608578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.