Evidence map›Paper›PMID 37188663›Full record

ArticleNature communications2023

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.

Hanna M Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati, Selina M Yogeshwar, Ryan P Hillary, Otto Jolanki, Juliette Faraco, Mali Einen and 81 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Narcolepsy is (not) an autoimmune disease.Nature reviews. Neurology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Narcolepsy and rapid eye movement sleep.Journal of sleep research · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

91 authors at 20 institutions in 28 countries.

Hanna M OllilaStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Eilon SharonDepartment of Genetics, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0002-1262-350X
Ling LinStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Nasa Sinnott-ArmstrongDepartment of Genetics, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0003-4490-0601
Aditya AmbatiStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.ORCID 0000-0001-8462-3552
Selina M YogeshwarStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Ryan P HillaryStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Otto JolankiDepartment of Genetics, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-8601-4849
Juliette FaracoStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Mali EinenStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Guo LuoStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Jing ZhangStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA.
Fang HanDivision of Sleep Medicine, The Peking University People's Hospital, Beijing, China.
Han YanDivision of Sleep Medicine, The Peking University People's Hospital, Beijing, China.
Xiao Song DongDivision of Sleep Medicine, The Peking University People's Hospital, Beijing, China.
Jing LiDivision of Sleep Medicine, The Peking University People's Hospital, Beijing, China.
Jun ZhangDepartment of Neurology, The Peking University People's Hospital, Beijing, China.
Seung-Chul HongDepartment of Psychiatry, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
Tae Won KimDepartment of Psychiatry, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
Yves DauvilliersSleep-Wake Disorders Center, National Reference Network for Narcolepsy, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; Institute for Neurosciences of Montpellier (INM), INSERM, Université Montpellier 1, Montpellier, France.
Lucie BarateauSleep-Wake Disorders Center, National Reference Network for Narcolepsy, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; Institute for Neurosciences of Montpellier (INM), INSERM, Université Montpellier 1, Montpellier, France.
Gert Jan LammersDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Rolf FronczekDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Geert MayerHephata Klinik, Schimmelpfengstr. 6, 34613, Schwalmstadt, Germany.
Joan SantamariaNeurology Service, Institut de Neurociències Hospital Clínic, University of Barcelona, Barcelona, Spain.
Isabelle ArnulfSleep Disorder Unit, Pitié-Salpêtrière Hospital, Assistance Publique-Hopitaux de Paris, 75013, Paris, France.ORCID 0000-0002-2240-2516
Stine Knudsen-HeierNorwegian Centre of Expertise for Neurodevelopment Disorders and Hypersomnias (NevSom), Department of Rare Disorders, Oslo University Hospital and University of Oslo, Oslo, Norway.
May Kristin Lyamouri BredahlNorwegian Centre of Expertise for Neurodevelopment Disorders and Hypersomnias (NevSom), Department of Rare Disorders, Oslo University Hospital and University of Oslo, Oslo, Norway.
Per Medbøe ThorsbyHormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-9615-1035
Giuseppe PlazziDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Ugo Foscolo 7, 40123, Bologna, Italy.
Fabio PizzaDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Ugo Foscolo 7, 40123, Bologna, Italy.
Monica MorescoDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Ugo Foscolo 7, 40123, Bologna, Italy.
Catherine CroweMater Private Hospital, Dublin 7, Ireland.
Stephen K Van den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-5599-8387
Michel LecendreuxPediatric Sleep Center and National Reference Center for Narcolepsy and Idiopathic Hypersomnia Hospital Robert Debre, Paris, France.
Patrice BourginDepartment of Sleep Medicine, Strasbourg University Hospital, Strasbourg University, Strasbourg, France.
Takashi KanbayashiDepartment of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.
Francisco J Martínez-OrozcoSleep Unit. Clinical Neurophysiology Service. San Carlos University Hospital. University Complutense of Madrid, Madrid, Spain.
Rosa Peraita-AdradosSleep and Epilepsy Unit, Clinical Neurophysiology Service, Gregorio Marañón University General Hospital and Research Institute, University Complutense of Madrid (UCM), Madrid, Spain.ORCID 0000-0002-4172-4000
Antonio BenetóSleep Unit. Medical Center Valencia, Valencia, Spain.
Jacques MontplaisirCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur and Department of Neurosciences, University of Montréal, Montréal, QC, Canada.
Alex DesautelsCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur and Department of Neurosciences, University of Montréal, Montréal, QC, Canada.
Yu-Shu HuangDepartment of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan.
FinnGen
Poul JennumDanish Center for Sleep Medicine, Department of Clinical Neurophysiology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark.
Sona NevsimalovaDepartment of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hosptal, Prague, Czech Republic.ORCID 0000-0003-0083-3742
David KemlinkDepartment of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hosptal, Prague, Czech Republic.
Alex IranzoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Sebastiaan OvereemSleep Medicine Center Kempenhaeghe, P.O. Box 61, 5590 AB, Heeze, The Netherlands.ORCID 0000-0002-6445-9836
Aleksandra WierzbickaDepartment of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland.
Peter GeislerDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Karel SonkaDepartment of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hosptal, Prague, Czech Republic.ORCID 0000-0001-5773-9656
Makoto HondaDepartment of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Birgit HöglDepartment of Neurology, Medical University Innsbruck (MUI), Innsbruck, Austria.
Ambra StefaniDepartment of Neurology, Medical University Innsbruck (MUI), Innsbruck, Austria.
Fernando Morgadinho CoelhoUniversidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo, Brazil.
Vilma MantovaniCenter for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, Bologna, Italy.ORCID 0000-0001-9465-8572
Eva FeketeovaNeurology Department, Medical Faculty of P. J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic.ORCID 0000-0002-7746-3797
Mia WadeliusDepartment of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-6368-2622
Niclas ErikssonDepartment of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-2152-4343
Hans SmedjeDivision of Child and Adolescent Psychiatry, Karolinska Institutet, Stockholm, Sweden.
Pär HallbergDepartment of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-3465-3280
Per Egil HeslaColiseum on Majorstua Clinic, Oslo, Norway.
David RyeDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Zerrin PelinFaculty of Health Sciences, Hasan Kalyoncu University, Gaziantep, Turkey.
Luigi Ferini-StrambiSleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy.
Claudio L BassettiNeurology Department, EOC, Ospedale Regionale di Lugano, Lugano, Ticino, Switzerland.
Johannes MathisDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Ramin KhatamiDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Adi AranShaare Zedek Medical Center, Jerusalem, Israel.
Sheela NampoothiriDepartment of Pediatric Genetics, Amrita Institute of Medical Sciences & Research Centre, Kerala, India.ORCID 0000-0002-9575-0722
Tomas OlssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ingrid KockumDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0867-4726
Markku PartinenHelsinki Sleep Clinic, Vitalmed Research Centre, Helsinki, Finland.
Markus PerolaUniversity of Helsinki, Institute for Molecular Medicine, Finland (FIMM) and Diabetes and Obesity Research Program. University of Tartu, Estonian Genome Center, Tartu, Estonia.
Birgitte R KornumDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2515-9451
Sina RuegerSwiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0003-2848-9242
Juliane WinkelmannInstitute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-3074-599X
Taku MiyagawaDepartment of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hiromi ToyodaDepartment of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Seik-Soon KhorDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-6809-4731
Mihoko ShimadaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Manuel RivasDepartment of Biomedical Data Science-Administration, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-1457-9925
Jonathan K PritchardDepartment of Genetics, Stanford University, Stanford, CA, 94305, USA.
Neil RischDept. Epidemiology and Biostatistics, UCSF, 513 Parnassus Avenue, San Francisco, CA, 94117, USA.ORCID 0000-0002-4126-2061
Zoltan KutalikSwiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0001-8285-7523
Ruth O'HaraDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Joachim HallmayerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Chun Jimmie YeDepartment of Epidemiology & Biostatistics, Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6560-3783
Emmanuel J MignotStanford University, Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, 94304, USA. mignot@stanford.edu.ORCID 0000-0002-6928-5310
University of Helsinki · FIHospital District of Helsinki and Uusimaa · FIFinnish Institute for Health and Welfare · FITampere University · FINorthern Ostrobothnia Hospital District · FIVarsinais-Suomen Sairaanhoitopiiri · FIGlaxoSmithKline (United Kingdom) · GBAbbVie (United States) · USPfizer (United States) · USPirkanmaa Hospital District · FIStanford University · USBroad Institute · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USJanssen (United States) · USAstraZeneca (United Kingdom) · GBBiogen (United States) · USBoehringer Ingelheim (Germany) · DEPeking University · CNUniversity of Oulu · FIUniversity of Turku · FI

Funding

SPECTRUM OF NARCOLEPSY AND ITS SYMPTOMSP50NS023724 · NINDS · STANFORD UNIVERSITY · PI MIGNOT, EMMANUEL J · 1986 to 2016
$18.9M
Depression susceptibility genes and networks: expression, eQTL and GWAS analysisRC2MH089916 · NIMH · STANFORD UNIVERSITY · PI LEVINSON, DOUGLAS FREDERICK · 2009 to 2010
$3.4M
Pandemrix and T Cell Immunology in NarcolepsyR01AI144798 · NIAID · STANFORD UNIVERSITY · PI MIGNOT, EMMANUEL J · 2021 to 2024
$2.6M
NIAID NIH HHS R01 AI144798NIMH NIH HHS RC2 MH089916NINDS NIH HHS P50 NS023724
6 · The paper itself

Abstract

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.

Indexed as

Autoimmune DiseasesInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesNarcolepsyAutoimmunityHumansInfluenza Vaccines

Identifiers

PMID37188663
PMCPMC10185546
OpenAlexW4376642583

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.