Evidence map›Paper›PMID 37188495›Full record

ArticleMolecular pharmacology2023

A Point Mutation at C151 of

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto, Thomas W Kensler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

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  12. SoloxoloneInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tonibelle Gatbonton-SchwagerTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Yoko YagishitaTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Tanvi JoshiTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Nobunao WakabayashiTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Harini SrinivasanTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Takafumi SuzukiTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Masayuki YamamotoTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.).
Thomas W KenslerTranslational Research Program (T.G.-S., Y.Y., T.J., N.W., T.W.K.) and Genomics & Bioinformatics (H.S.), Fred Hutchinson Cancer Center, Seattle, Washington and Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan (T.S., M.Y.) tkensler@fredhutch.org.ORCID 0000-0002-6676-261X
Fred Hutch Cancer Center · USTohoku University · JP

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Targeting Nrf2 for Cancer ChemopreventionR35CA197222 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KENSLER, THOMAS W · 2015 to 2021
$6.7M
NCI NIH HHS P30 CA015704NCI NIH HHS R35 CA197222
6 · The paper itself

Abstract

Bardoxolone methyl (CDDO-Me) is an oleanane triterpenoid in late-stage clinical development for the treatment of patients with diabetic kidney disease. Preclinical studies in rodents demonstrate the efficacy of triterpenoids against carcinogenesis and other diseases, including renal ischemia-reperfusion injury, hyperoxia-induced acute lung injury, and immune hepatitis. Genetic disruption of

Indexed as

HepatitisOleanolic AcidAnimalsCysteineCytoprotectionKelch-Like ECH-Associated Protein 1MiceMice, KnockoutNF-E2-Related Factor 2Point MutationSignal Transductionbardoxolone methylCysteineKeap1 protein, mouseKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Oleanolic Acid

Identifiers

PMID37188495
PMCPMC10353147
OpenAlexW4376610098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.